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Donor Considerations in Fecal Microbiota Transplantation

  • Danielle BarnesEmail author
  • K. T. Park
Pediatric Gastroenterology (S Orenstein, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatric Gastroenterology

Abstract

Purpose of Review

Tremendous acceleration has been made in understanding the gut microbiota in the past decade and, with it, further understanding of the pathologic role of dysbiosis and the use of fecal microbiota transplantation (FMT) as therapy. FMT has been studied in many disease states including the most common indication of Clostridium difficile infection (CDI), though many questions regarding stool donor selection remain.

Recent Findings

Though traditionally, one donor has provided stool for one patient, research is underway to explore many donor selection considerations from the use of pooled donor stool to selection of a high diversity donor. It is well-known that dietary intake shapes the gut microbiota and the potential implications of this on FMT donor selection are being explored.

Summary

Though further high-quality research is needed, optimizing the fecal microbiota inoculum holds great promise.

Keywords

Fecal microbiota transplant Clostridium difficile infection FMT donor Competitive donor 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Disclosures

The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York (outside the USA) 2017

Authors and Affiliations

  1. 1.Department of Pediatrics, Division of Gastroenterology, Hepatology, and NutritionNaval Medical Center San DiegoSan DiegoUSA
  2. 2.Department of Pediatrics, Division of Gastroenterology, Hepatology and NutritionStanford Children’s HealthPalo AltoUSA

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