Management of Hepatic Adenomatosis

Liver (B Bacon, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Liver


Hepatic adenomatosis (HeAs) is a rare clinical entity defined by the presence of 10 or more hepatic adenomas (HA) within the background of an otherwise normal liver parenchyma, in the absence of glycogen storage disease or anabolic steroid use. HA is a benign tumor associated with oral contraceptive use. Recent advances in pathogenesis and classification of HA have questioned the distinction between these two diseases. HA are currently classified into four different subtypes with genotypic and phenotypic correlation: HNF-1a inactivated HA, B-catenin activated HA, inflammatory HA, and undetermined subtype. The clinical presentation of HA depends on the lesion size and the subtype. MRI using hepatospecific contrast agents is helpful in diagnosing the most common subtypes. When diagnosis is uncertain, biopsy with immunohistochemistry is used to diagnose and classify the lesions. Management is governed by the molecular subtype and tumor size. Pregnancy is not routinely discouraged but management is individualized.


Hepatic adenomatosis Hepatic adenoma Classification Management Diagnosis Pregnancy Resection Liver transplant 



The authors would like to acknowledge the help of Dr. David Reich, Dr. Santiago Munoz, and Dr. Nancy Moshen for their guidance and edits

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Conflict of Interest

All authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Manish Thapar
    • 1
    • 2
  • Oleg Grapp
    • 1
  • Constantine Fisher
    • 1
  1. 1.Department of MedicineDrexel University College of MedicinePhiladelphiaUSA
  2. 2.Division of Gastroenterology & HepatologyDrexel University College of MedicinePhiladelphiaUSA

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