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Environmental Triggers for IBD

  • Aoibhlinn O’Toole
  • Joshua KorzenikEmail author
Inflammatory Bowel Disease (S Hanauer, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Inflammatory Bowel Disease

Abstract

The fundamental elucidation of how environmental influences provoke the initiation of disease as well as flares of inflammatory bowel disease (IBD) remains incomplete. The current understanding of these diseases suggests that ulcerative colitis (UC) and Crohn’s disease (CD) result from poorly defined interactions between genetic and environmental factors which culminate in the pathologic effects and clinical manifestations of these diseases. The genetic variant appears not sufficient itself to lead to the development of the clinical disease, but likely must combine with the environmental factors. The intestinal microbiome is pivotal to IBD development. A greater understanding of the contribution of these factors to dysbiosis is critical, and we aspire to restoring a healthy microbiome to treat flares and ideally prevent the development of IBD and its complications. This article aims to place the environmental influences in the context of their potential contribution to the development of the pathophysiology of IBD.

Keywords

Inflammatory bowel disease Crohn’s Ulcerative colitis Microbiome Environment Triggers Pathophysiology Dysbiosis 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Aoibhliin O’Toole declares no conflict of interest. Joshua Korzenik has served as an IBD consultant for Abbvie, Empiramed, Pfizer, Vithera, Prometheus, and Janssen; he has received research/grant support from Abbvie, and Warner-Chilcott and has served as a member of the Data Safety Monitoring Board for Roche.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.BWH Crohn’s and Colitis CenterBrigham and Women’s HospitalBostonUSA

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