Endoscopic Submucosal Dissection for Malignant Esophageal Lesions

  • Hazem Hammad
  • Tonya Kaltenbach
  • Roy Soetikno
Esophagus (L Gerson, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Esophagus


The incidence of esophageal cancer has been increasing while the prognosis remains very poor. Endoscopic submucosal dissection (ESD) was developed in Japan for en bloc resection of early gastric cancer with excellent results. The use of ESD in early squamous cell cancer (SCC) of the esophagus in Japan has been increasing with long-term results comparable to those in early gastric cancer. The use of ESD in Barrett’s neoplasia in western countries has been challenged by the low complete resection rates and the risk of metachronous lesions from surrounding non-dysplastic Barrett’s epithelium. Efforts to combine ESD with other treatment modalities such as radiofrequency ablation in Barrett’s neoplasia and chemoradiation in SCC appear to be promising. The use of steroid therapy (local or systemic) has been demonstrated to prevent post-ESD stenosis, which is the most common complication after esophageal ESD.


Endoscopy Resection Esophagus Cancer 



Squamous cell carcinoma


Endoscopic mucosal resection


Endoscopic submucosal dissection


National Comprehensive Cancer Network


Esophago-gastric junction


Chemoradiation therapy


Endoscopic submucosal tunnel dissection


Intraepithelial papillary capillary loops


Compliance with Ethics Guidelines

Conflict of Interest

Dr. Hammad has nothing to disclose.

Dr. Kaltenbach and Dr. Soetikno report grants from Olympus America outside the submitted work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Harry S. Truman Memorial Veterans HospitalUniversity of Missouri Hospital and ClinicsColumbiaUSA
  2. 2.Veterans Affairs Palo AltoStanford University School of MedicinePalo AltoUSA
  3. 3.Division of GastroenterologyUniversity of Missouri Hospital and ClinicsColumbiaUSA

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