Interval Colorectal Cancers: What and Why

GI Oncology (R Bresalier, Section Editor)

DOI: 10.1007/s11894-014-0375-3

Cite this article as:
le Clercq, C.M.C. & Sanduleanu, S. Curr Gastroenterol Rep (2014) 16: 375. doi:10.1007/s11894-014-0375-3
Part of the following topical collections:
  1. Topical Collection on GI Oncology


An increasing number of studies now indicate that colonoscopic examination is not perfect in preventing colorectal cancer (CRC), especially of the proximal colon. Several factors can be implicated in the occurrence of interval CRCs—further referred to as postcolonoscopy CRCs-, such as missed, incompletely resected lesions and newly developed cancers. Missed lesions represent by far the dominant cause of postcolonoscopy CRCs, with nonpolypoid (flat or depressed) neoplasms and sessile serrated polyps playing a significant role. Molecular events underlying progression of such lesions may further augment the cancer risk. In this article, we review the literature about postcolonoscopy CRC risk and the most common explanations. We discuss potential implications, paying special attention to improvements required in education and training.


Colorectal cancer Interval colorectal cancer Postcolonoscopy colorectal cancer Nonpolypoid colorectal neoplasm Serrated polyp Endoscopy Detection Management 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Gastroenterology and Hepatology, Department of Internal MedicineMaastricht University Medical CenterAZ, MaastrichtThe Netherlands

Personalised recommendations