Intestinal Microbiota and its Role in Irritable Bowel Syndrome (IBS)
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Gut microbiota alterations are increasingly being recognized as an important factor in the pathogenesis and pathophysiology of Irritable bowel syndrome (IBS). The onset of IBS symptoms after a bout of gastroenteritis comprises one of the strongest indications for the importance of gut microbiota for IBS. Moreover, recent studies have identified several susceptibility genes for IBS involved in the innate immunity and recognition of bacteria but also maintaining the integrity of the intestinal barrier. During recent years, it has also been demonstrated that IBS patients, or subgroups thereof, may have an altered microbiota composition relative to healthy individuals, mainly based on the analysis of fecal microbiota. Moreover, a positive effect of treatment with non-absorbable antibiotics and probiotics in IBS provides further indirect support for the relevance of gut microbiota alterations in IBS.
KeywordsIrritable bowel syndrome IBS Post-infectious IBS Microbiota Inflammation Antibiotics Probiotics SIBO
Conflict of Interest
Dr. L. Öhman has been a consultant for Abbvie, and has received grant support from The Health & Medical Care Committee of the Regional Executive Board, Region Västra Götaland, Swedish Medical Research Council , Swedish Society of Medicine, VINNOVA.
Dr. M Simrén has been a consultant for Danone Research, Shire-Movetis, and Almirall; grant support from Danone Research, and payment for development of educational presentations from MSD, Abbott, Almirall, Shire-Movetis, Tillotts, and Vifor Pharma.
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