Natural History of Cirrhosis

Liver (B Bacon, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Liver

Abstract

Significant strides have been made in the last few years in advancing our knowledge of the natural history of cirrhosis. These include (1) a better understanding of prognosis in compensated and decompensated cirrhosis, (2) improved estimates of the natural course of variceal bleeding in patients receiving standard of care therapy, (3) recognition of renal failure and infection as important determinants of mortality in the clinic course, (4) realization of the importance of hepatic venous pressure gradient as a marker of prognosis, progression, and treatment response, and (5) evolution of noninvasive studies of liver stiffness as potential predictors of decompensation. Further studies identifying cirrhotics at highest risk of transitioning from a compensated state to a decompensated state will be important in order to alter the natural history of cirrhosis.

Keywords

Variceal bleed Prognosis Survival Acute-on-chronic liver failure Hepatic encephalopathy Prognosis MELD HVPG 

Abbreviations

HE

Hepatic encephalopathy

LT

Liver transplantation

MELD

Model for end stage liver disease

INR

International normalized ratio

GFR

Glomerular filtration rate

HCC

Hepatocellular carcinoma

DRI

Donor risk index

HR

Hazard ratio

HCV

Chronic viral hepatitis C

Na

Serum sodium

TIPS

Transjugular Intrahepatic portosystemic shunt

c statistic

Concordance statistic

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Gastroenterology and HepatologyMayo Clinic College of MedicineRochesterUSA

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