Natural History of Cirrhosis

Liver (B Bacon, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Liver


Significant strides have been made in the last few years in advancing our knowledge of the natural history of cirrhosis. These include (1) a better understanding of prognosis in compensated and decompensated cirrhosis, (2) improved estimates of the natural course of variceal bleeding in patients receiving standard of care therapy, (3) recognition of renal failure and infection as important determinants of mortality in the clinic course, (4) realization of the importance of hepatic venous pressure gradient as a marker of prognosis, progression, and treatment response, and (5) evolution of noninvasive studies of liver stiffness as potential predictors of decompensation. Further studies identifying cirrhotics at highest risk of transitioning from a compensated state to a decompensated state will be important in order to alter the natural history of cirrhosis.


Variceal bleed Prognosis Survival Acute-on-chronic liver failure Hepatic encephalopathy Prognosis MELD HVPG 



Hepatic encephalopathy


Liver transplantation


Model for end stage liver disease


International normalized ratio


Glomerular filtration rate


Hepatocellular carcinoma


Donor risk index


Hazard ratio


Chronic viral hepatitis C


Serum sodium


Transjugular Intrahepatic portosystemic shunt

c statistic

Concordance statistic


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Gastroenterology and HepatologyMayo Clinic College of MedicineRochesterUSA

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