Helicobacter pylori in Gastric Malignancies
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Helicobacter pylori infection remains common worldwide and is significantly associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT)lymphoma. This article reviews recent developments in the field of H. pylori with an emphasis on mechanisms of carcinogenesis, and the bacterial, environmental and host factors that may alter risk of developing gastric cancer or gastric MALT lymphoma. The topic of eradication of H. pylori to prevent the development of malignancy and the possibility of a vaccine against H. pylori are also explored.
KeywordsHelicobacter Pylori Gastric Malignancy Adenocarcinoma MALT Lymphoma Cancer Stomach Mucosa-associated lymphoid tissue
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- 4.Japanese Research Society for Gastric Cancer: The General Rules for the Gastric Cancer Study in Surgery and Pathology. Kanahara Shuppan 1993.Google Scholar
- 5.Edge SB, Byrd DR, Compton CC, et al.: American Joint Committee on Cancer Staging Manual 2010. 117.Google Scholar
- 7.Isaacson PG: Gastrointestinal lymphomas and lymphoid hyperplasias. Neoplastic Haematolpathology 1992:953.Google Scholar
- 8.• de Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607–15. This is an interesting report indicating that of the 12.7 million new cancers occurring in 2008, the population attributable fraction due to infection was over 16% with H. pylori, hepatitis B and C and human papilloma virus responsible for 1.9 million cases. The fraction was higher (almost 23%) in the less developed world.PubMedCrossRefGoogle Scholar
- 16.Cho Y, Lee DH, Oh HS, et al.: Higher Prevalence of Obesity in Gastric Cardia Adenocarcinoma Compared to Gastric Non-Cardia Adenocarcinoma. Digestive Diseases and Sciences 2012.Google Scholar
- 19.Sokolova O, Vieth M, Naumann M: Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. Gut 2012Google Scholar
- 28.Saito M, Suzuki K, Maeda T, et al. The accumulation of DNA demethylation in Sat α in normal gastric tissues with Helicobacter pylori infection renders susceptibility to gastric cancer in some individuals. Oncology Rep. 2012;27(6):1717–25.Google Scholar
- 32.Lu XX, Yu JL, Ying LS, et al.: Stepwise cumulation of RUNX3 methylation mediated by Helicobacter pylori infection contributes to gastric carcinoma progression. Cancer 2012Google Scholar
- 37.• Malfertheiner P, Megraud F, O'Morain CA, et al. Management of Helicobacter pylori infection–the Maastricht IV/ Florence Consensus Report. Gut. 2012;61(5):646–64. This important consensus arising from a meeting of 44 experts from 24 countries addresses treatment of H. pylori infection and strategies for reducing incidence of gastric adenocarcinoma secondary to H. pylori. PubMedCrossRefGoogle Scholar
- 42.• Lee YC, Chen TH, Chiu HM, et al.: The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. Gut 2012. This unique study reports outcomes from two time periods 1995-2003 and 2004-208 before and after a national H. pylori eradication program in Taiwan. Google Scholar
- 44.• Maehata Y, Nakamura S, Fujisawa K, et al. Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc. 2012;75(1):39–46. This retrospective multicenter study reports results from longer follow-up which showed a lower rate of new gastric cancers after endoscopic mucosal resection in the patients in whom infection was eradicated compared those in whom infection persisted but only up to 5 years. With longer-term follow-up the results were no longer significant. PubMedCrossRefGoogle Scholar
- 48.Lydyard P, Grossi C: Secondary lymphoid organs and tissues. Immunology 1996Google Scholar
- 57.• Nakamura S, Sugiyama T, Matsumoto T, et al. Long-term clinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan. Gut. 2012;61:507. This recent multicenter Japanese study describes the follow-up of 420 patients with low-grade MALT lymphoma for three or more years after H. pylori eradication with a 77 % response. PubMedCrossRefGoogle Scholar
- 68.Wang L, Liu XF, Yun S, et al. Protection against Helicobacter pylori infection by a trivalent fusion vaccine based on a fragment of urease B-UreB414. J Microbiol (South Korea). 2010;48(2):223–8.Google Scholar
- 69.Bauer B, Meyer TF: The Human Gastric Pathogen Helicobacter pylori and Its Association with Gastric Cancer and Ulcer Disease. Ulcers 2011. doi: 10.1155/2011/340157.