Current Gastroenterology Reports

, Volume 14, Issue 3, pp 226–235

Gastroesophageal Reflux in Cystic Fibrosis: Current Understandings of Mechanisms and Management

Pediatric Gastroenterology (SR Orenstein, Section Editor)

Abstract

Cystic fibrosis (CF) is an inherited disease that affects both the lungs and the digestive system in children and adults. Thick mucus fills the gut and blocks lumens of the pancreas and hepatobiliary systems, creating insufficient pancreas function and liver disease. Chronic gastrointestinal (GI) complications, including intestinal obstruction, occur in neonates, and poor digestion and gastroesophageal reflux disease (GERD) in children. Although GI symptoms tend to improve with age, CF and associated GERD eventually create respiratory insufficiency; the only available treatment option at this stage is a bilateral lung transplant, which carries considerable morbidity and mortality. While GERD may reoccur as a complication of lung transplantation, GERD symptoms are often reduced following a fundoplication.

Keywords

Children Chronic cough Cystic fibrosis Gastric hyperacidity Fundoplication GER (gastroesophageal reflux) Impedance (LES) lower esophageal sphincter pH monitoring 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Center for Advanced Research in Neuromuscular Gastrointestinal DisordersThe Ohio State University, Nationwide Children’s HospitalColumbusUSA
  2. 2.Fellowship in the Advanced Training in Gastrointestinal Motility and Functional DisordersThe Ohio State University, Nationwide Children’s HospitalColumbusUSA
  3. 3.Division of Pediatric GastroenterologyThe Ohio State University College of Medicine, Nationwide Children’s HospitalColumbusUSA

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