Current Gastroenterology Reports

, Volume 14, Issue 3, pp 262–269 | Cite as

Management and Prognosis of Acute Liver Failure in Children

  • Daniel D’Agostino
  • Silvia Diaz
  • Maria Camila Sanchez
  • Gustavo Boldrini
Pediatric Gastroenterology (SR Orenstein, Section Editor)


Although the etiologies of pediatric acute liver failure (ALF) are diverse, ultimate pathophysiologic pathways and management challenges for these disorders, usually lethal in the pre-transplant era, are similar. This review considers particularly the mechanisms of, and monitoring for, intracranial hypertension and coagulopathy; summarizes detailed advice for management of the ALF-associated failures of multiple body systems; and reviews the variety of prognostic scores available to guide management and assist in choosing the patients most apt to benefit from liver transplantation and the optimal timing for such transplantation.


Acute liver failure Children MELD/PELD Liver transplantation Hepatic encephalopathy Hypothermia 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Daniel D’Agostino
    • 1
  • Silvia Diaz
    • 2
  • Maria Camila Sanchez
    • 1
  • Gustavo Boldrini
    • 1
  1. 1.Gastroenterology-Hepatology Division, Liver-Intestinal Transplantation Center, Hospital Italiano de Buenos AiresBuenos AiresArgentina
  2. 2.Intensive Care Unit. Department of PediatricsHospital Italiano de Buenos AiresBuenos AiresArgentina

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