Management and Prognosis of Acute Liver Failure in Children
Although the etiologies of pediatric acute liver failure (ALF) are diverse, ultimate pathophysiologic pathways and management challenges for these disorders, usually lethal in the pre-transplant era, are similar. This review considers particularly the mechanisms of, and monitoring for, intracranial hypertension and coagulopathy; summarizes detailed advice for management of the ALF-associated failures of multiple body systems; and reviews the variety of prognostic scores available to guide management and assist in choosing the patients most apt to benefit from liver transplantation and the optimal timing for such transplantation.
KeywordsAcute liver failure Children MELD/PELD Liver transplantation Hepatic encephalopathy Hypothermia
No potential conflicts of interest relevant to this article were reported.
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