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Natural history and complications of IBD

  • Morten H. VatnEmail author
Article

Abstract

Inflammatory bowel diseases (IBD), mainly ulcerative colitis and Crohn’s disease, are chronic, heterogenic, lifelong illnesses with young age of onset and a great potential for disability. The natural history of these diseases is influenced by multiple factors of environmental and genetic origin. Multidisciplinary research has increased our knowledge of the mechanisms involved during the development and outcome of the diseases, including disease complications. Immunomodulatory treatment has demonstrated greatly improved efficacy in moderate to severe disease activity. The long-term effect on the natural course of disease and sustained reduced burden on society over many years require study. This article summarizes recent knowledge on factors influencing the natural history of IBD, including the impact of treatment. Increased understanding of disease mechanisms is needed as a basis for new treatment strategies in the future.

Keywords

Ulcerative Colitis Pyoderma Gangrenosum Extraintestinal Manifestation Complicated Disease Aphthous Stomatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.The Institute of Clinical Epidemiology and Molecular Biology (EpiGen), Faculty Division AHUSUniversity of Oslo, Medical Clinic, Oslo University Hospital, RikshospitaletOsloNorway

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