Current Gastroenterology Reports

, Volume 10, Issue 1, pp 73–80 | Cite as

Nonalcoholic fatty liver disease as a component of the metabolic syndrome

  • Mouen A. Khashab
  • Suthat Liangpunsakul
  • Naga ChalasaniEmail author


Nonalcoholic fatty liver disease (NAFLD) is an important cause of liver-related morbidity and mortality. The association between NAFLD and the metabolic syndrome is well established: the presence of the metabolic syndrome signifies advanced histology in NAFLD patients. Emerging data indicate that patients with NAFLD have a significantly higher prevalence of cardiovascular disease. This article reviews the definitions of the two syndromes, their association, and the cardiovascular risk conferred by both when they occur separately and together. This review also discusses management options for the syndromes, including treating the individual components of the metabolic syndrome in NAFLD patients.


Metabolic Syndrome Metformin NASH Rosiglitazone Pioglitazone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Mouen A. Khashab
  • Suthat Liangpunsakul
  • Naga Chalasani
    • 1
    Email author
  1. 1.Indiana University School of MedicineIndianapolisUSA

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