Current Gastroenterology Reports

, Volume 6, Issue 2, pp 119–125 | Cite as

Novel therapies for pancreatic adenocarcinoma

  • Simona M. Pino
  • Henry Q. Xiong
  • David McConkey
  • James L. Abbruzzese


Despite advances in our understanding of the molecular and genetic basis of pancreatic cancer, the disease remains a clinical challenge. Gemcitabine, the standard chemotherapy for pancreatic cancer, offers modest improvement of tumor-related symptoms and marginal advantage of survival. New approaches, alone and in combination with gemcitabine, are being developed to combat this cancer. In this article we review the current status of investigations into several classes of agents: matrix metalloproteinase inhibitors; farnesyl transferase inhibitors; epidermal growth factor receptor inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors; cyclooxygenase-2 inhibitors, and others. The scientific rationale, mechanism of action, and clinical trial data for these novel agents are discussed.


Epidermal Growth Factor Receptor Gemcitabine Celecoxib Pancreatic Adenocarcinoma Epidermal Growth Factor Receptor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Simona M. Pino
    • 1
  • Henry Q. Xiong
    • 1
  • David McConkey
    • 1
  • James L. Abbruzzese
    • 1
  1. 1.Department of Gastrointestinal Medical OncologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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