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Current Diabetes Reports

, 19:155 | Cite as

Diagnostic Strategies for Gestational Diabetes Mellitus: Review of Current Evidence

  • Chun-Heng Kuo
  • Hung-Yuan LiEmail author
Diabetes and Pregnancy (M-F Hivert and CE Powe, Section Editors)
  • 25 Downloads
Part of the following topical collections:
  1. Topical Collection on Diabetes and Pregnancy

Abstract

Purpose of Review

Currently, the diagnosis of gestational diabetes mellitus (GDM) lacks uniformity. Several controversies are still under debate, especially on the method of screening and diagnosis. This review focuses on recent literature and provides current evidence for the screening and diagnosis of GDM.

Recent Findings

Selective screening would miss a significant number of women with GDM. In contrast, universal screening has been shown to be cost-effective, compared with selective screening, and is recommended by many medical societies. For the diagnostic methods for GDM, most observational cohort studies reported that the one-step method is associated with improved pregnancy outcomes and is cost-saving or cost-effective, compared with the two-step method, although these findings should be confirmed in the upcoming randomized controlled trials which compare the performance of one-step and two-step methods. On the other hand, the methods of early screening or diagnosis of GDM are varied, and current evidence does not justify their use during early pregnancy.

Summary

In conclusion, current evidence favors universal screening for GDM using the one-step method. Early screening for GDM is not favorably supported by the literature.

Keywords

Gestational diabetes mellitus Screening Diagnostic strategy Risk factor modeling Oral glucose tolerance tests 

Notes

Compliance with Ethical Standards

Conflict of Interest

Chun-Heng Kuo and Hung-Yuan Li declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

All reported studies with human subjects performed by the authors have been previously published and complied with the ethical standards of institutional research committee and with the Helsinki declaration and its amendments.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28(12):1039–57.CrossRefGoogle Scholar
  2. 2.
    ACOG Practice Bulletin No. 190. gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49–64.  https://doi.org/10.1097/aog.0000000000002501.CrossRefGoogle Scholar
  3. 3.
    Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002.  https://doi.org/10.1056/NEJMoa0707943.CrossRefPubMedGoogle Scholar
  4. 4.
    Wei JN, Li HY, Sung FC, Lin CC, Chiang CC, Li CY, et al. Birth weight correlates differently with cardiovascular risk factors in youth. Obesity (Silver Spring, Md). 2007;15(6):1609–16.  https://doi.org/10.1038/oby.2007.190.CrossRefGoogle Scholar
  5. 5.
    • Scholtens DM, Kuang A, Lowe LP, Hamilton J, Lawrence JM, Lebenthal Y, et al. Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): maternal glycemia and childhood glucose metabolism. Diabetes Care. 2019;42(3):381–92.  https://doi.org/10.2337/dc18-2021. The results of HAPO follow-up study showed that across the maternal glucose spectrum, exposure to higher levels in utero is significantly associated with childhood glucose and insulin resistance independent of maternal and childhood BMI and family history of diabetes. This long-term follow-up study provide more data on long-term outcomes and can be used to refine the evaluation of cost-effectiveness in the future. CrossRefPubMedGoogle Scholar
  6. 6.
    Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000;49(12):2208–11.CrossRefGoogle Scholar
  7. 7.
    No PB. 180: gestational diabetes mellitus. Obstet Gynecol. 2017;130(1):e17–37.  https://doi.org/10.1097/aog.0000000000002159.CrossRefGoogle Scholar
  8. 8.
    Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med. 2005;352(24):2477–86.  https://doi.org/10.1056/NEJMoa042973.CrossRefPubMedGoogle Scholar
  9. 9.
    Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Donovan L. Benefits and harms of treating gestational diabetes mellitus: a systematic review and meta-analysis for the U.S. Preventive Services Task Force and the National Institutes of Health Office of Medical Applications of research. Ann Intern Med. 2013;159(2):123–9.  https://doi.org/10.7326/0003-4819-159-2-201307160-00661.CrossRefPubMedGoogle Scholar
  10. 10.
    • Danyliv A, Gillespie P, O'Neill C, Tierney M, O'Dea A, McGuire BE, et al. The cost-effectiveness of screening for gestational diabetes mellitus in primary and secondary care in the Republic of Ireland. Diabetologia. 2016;59(3):436–44.  https://doi.org/10.1007/s00125-015-3824-0. This study in Ireland showed that universal screening for GDM, compared with no screening, was cost-saving and was associated with gains in quality of life. CrossRefPubMedGoogle Scholar
  11. 11.
    Werner EF, Pettker CM, Zuckerwise L, Reel M, Funai EF, Henderson J, et al. Screening for gestational diabetes mellitus: are the criteria proposed by the international association of the Diabetes and Pregnancy Study Groups cost-effective? Diabetes Care. 2012;35(3):529–35.  https://doi.org/10.2337/dc11-1643.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Benhalima K, Damm P, Van Assche A, Mathieu C, Devlieger R, Mahmood T, et al. Screening for gestational diabetes in Europe: where do we stand and how to move forward?: a scientific paper commissioned by the European Board & College of Obstetrics and Gynaecology (EBCOG). Eur J Obstet Gynecol Reprod Biol. 2016;201:192–6.  https://doi.org/10.1016/j.ejogrb.2016.04.002.CrossRefPubMedGoogle Scholar
  13. 13.
    Duran A, Saenz S, Torrejon MJ, Bordiu E, Del Valle L, Galindo M, et al. Introduction of IADPSG criteria for the screening and diagnosis of gestational diabetes mellitus results in improved pregnancy outcomes at a lower cost in a large cohort of pregnant women: the St. Carlos Gestational Diabetes Study. Diabetes care. 2014;37(9):2442–50.  https://doi.org/10.2337/dc14-0179.CrossRefPubMedGoogle Scholar
  14. 14.
    Farrar D, Duley L, Dowswell T, Lawlor DA. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. The Cochrane Database of Systematic Reviews. 2017;8:Cd007122.  https://doi.org/10.1002/14651858.CD007122.pub4.CrossRefPubMedGoogle Scholar
  15. 15.
    Farrar D, Simmonds M, Griffin S, Duarte A, Lawlor DA, Sculpher M, et al. The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation. Health Technology Assessment (Winchester, England). 2016;20(86):1–348.  https://doi.org/10.3310/hta20860.CrossRefPubMedCentralGoogle Scholar
  16. 16.
    Wu ET, Nien FJ, Kuo CH, Chen SC, Chen KY, Chuang LM, et al. Diagnosis of more gestational diabetes lead to better pregnancy outcomes: comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria. Journal of Diabetes Investigation. 2016;7(1):121–6.  https://doi.org/10.1111/jdi.12378.CrossRefPubMedGoogle Scholar
  17. 17.
    O’Sullivan JB, Mahan CM. Criteria for the oral glucose tolerance test in pregnancy. Diabetes. 1964;13:278–85.PubMedGoogle Scholar
  18. 18.
    O’Sullivan JB, Mahan CM, Charles D, Dandrow RV. Screening criteria for high-risk gestational diabetic patients. Am J Obstet Gynecol. 1973;116(7):895–900.CrossRefGoogle Scholar
  19. 19.
    Carpenter MW, Coustan DR. Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol. 1982;144(7):768–73.CrossRefGoogle Scholar
  20. 20.
    American Diabetes Association. Gestational diabetes mellitus. Diabetes Care. 1986;9(4):430–1.CrossRefGoogle Scholar
  21. 21.
    American College of Obstetricians and Gynecologists: Management of diabetes mellitus during pregnancy. ACOG Technical Bulletin #92. 1986.Google Scholar
  22. 22.
    National Institutes of Health consensus development conference statement. diagnosing gestational diabetes mellitus, 2013. Obstetrics and gynecology. 2013;122(2 Pt 1):358–69.  https://doi.org/10.1097/AOG.0b013e31829c3e64.CrossRefGoogle Scholar
  23. 23.
    Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676–82.  https://doi.org/10.2337/dc09-1848.CrossRefPubMedGoogle Scholar
  24. 24.
    American Diabetes Association. Standards of medical care in diabetes--2011. Diabetes care. 2011;34(Suppl 1):S11–61.  https://doi.org/10.2337/dc11-S011.CrossRefPubMedCentralGoogle Scholar
  25. 25.
    Blumer I, Hadar E, Hadden DR, Jovanovic L, Mestman JH, Murad MH, et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(11):4227–49.  https://doi.org/10.1210/jc.2013-2465.CrossRefPubMedGoogle Scholar
  26. 26.
    WHO Guidelines Approved by the Guidelines Review Committee. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Geneva: World Health Organization. Copyright (c) World Health Organization; 2013. p. 2013.Google Scholar
  27. 27.
    Hod M, Kapur A, Sacks DA, Hadar E, Agarwal M, Di Renzo GC, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on gestational diabetes mellitus: a pragmatic guide for diagnosis, management, and care. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2015;131(Suppl 3):S173–211.  https://doi.org/10.1016/s0020-7292(15)30007-2.CrossRefGoogle Scholar
  28. 28.
    Sacks DA, Hadden DR, Maresh M, Deerochanawong C, Dyer AR, Metzger BE, et al. Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the hyperglycemia and adverse pregnancy outcome (HAPO) study. Diabetes Care. 2012;35(3):526–8.  https://doi.org/10.2337/dc11-1641.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Agarwal MM, Dhatt GS, Othman Y. Gestational diabetes: differences between the current international diagnostic criteria and implications of switching to IADPSG. J Diabetes Complicat. 2015;29(4):544–9.  https://doi.org/10.1016/j.jdiacomp.2015.03.006.CrossRefPubMedGoogle Scholar
  30. 30.
    Cade TJ, Polyakov A, Brennecke SP. Implications of the introduction of new criteria for the diagnosis of gestational diabetes: a health outcome and cost of care analysis. BMJ Open. 2019;9(1):e023293.  https://doi.org/10.1136/bmjopen-2018-023293.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Idris N, Hatikah CC, Murizah M, Rushdan M. Universal versus selective screening for detection of gestational diabetes mellitus in a Malaysian population. Malays Fam Physician. 2009;4(2–3):83–7.PubMedPubMedCentralGoogle Scholar
  32. 32.
    Benhalima K, Mathieu C, Van Assche A, Damm P, Devlieger R, Mahmood T, et al. Survey by the European Board and College of Obstetrics and Gynaecology on screening for gestational diabetes in Europe. Eur J Obstet Gynecol Reprod Biol. 2016;201:197–202.  https://doi.org/10.1016/j.ejogrb.2016.04.003.CrossRefPubMedGoogle Scholar
  33. 33.
    Miailhe G, Kayem G, Girard G, Legardeur H, Mandelbrot L. Selective rather than universal screening for gestational diabetes mellitus? Eur J Obstet Gynecol Reprod Biol. 2015;191:95–100.  https://doi.org/10.1016/j.ejogrb.2015.05.003.CrossRefGoogle Scholar
  34. 34.
    • Benhalima K, Van Crombrugge P, Moyson C, Verhaeghe J, Vandeginste S, Verlaenen H, et al. Risk factor screening for gestational diabetes mellitus based on the 2013 WHO criteria. European Journal of Endocrinology. 2019;180(6):353–63.  https://doi.org/10.1530/eje-19-0117. In this Belgian retrospective cohort study, 1811 women received 75-g OGTT, and 231 (12.5%) of them were diagnosed with GDM by the WHO 2013 criteria. Applying the English, Irish, French and Dutch guidelines for risk factor-based screening would miss 48.1%, 36.8%, 36.4% and 33.3% of pregnant women with GDM, respectively. CrossRefPubMedGoogle Scholar
  35. 35.
    Cosson E, Benbara A, Pharisien I, Nguyen MT, Revaux A, Lormeau B, et al. Diagnostic and prognostic performances over 9 years of a selective screening strategy for gestational diabetes mellitus in a cohort of 18,775 subjects. Diabetes Care. 2013;36(3):598–603.  https://doi.org/10.2337/dc12-1428.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Di Cianni G, Volpe L, Casadidio I, Bottone P, Marselli L, Lencioni C, et al. Universal screening and intensive metabolic management of gestational diabetes: cost-effectiveness in Italy. Acta Diabetol. 2002;39(2):69–73.CrossRefGoogle Scholar
  37. 37.
    Cosson E, Cussac-Pillegand C, Benbara A, Pharisien I, Jaber Y, Banu I, et al. The diagnostic and prognostic performance of a selective screening strategy for gestational diabetes mellitus according to ethnicity in Europe. J Clin Endocrinol Metab. 2014;99(3):996–1005.  https://doi.org/10.1210/jc.2013-3383.CrossRefPubMedGoogle Scholar
  38. 38.
    American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S13–s27.  https://doi.org/10.2337/dc18-S002.CrossRefGoogle Scholar
  39. 39.
    Cheng AY. Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. Can J Diabetes. 2013;37(Suppl 1):S1–3.  https://doi.org/10.1016/j.jcjd.2013.01.009.CrossRefPubMedGoogle Scholar
  40. 40.
    Nankervis A, McIntyre HD, Moses RG, Ross GP, Callaway LK. Testing for gestational diabetes mellitus in Australia. Diabetes Care. 2013;36(5):e64.  https://doi.org/10.2337/dc12-2345.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Brown FM, Wyckoff J. Application of one-step IADPSG versus two-step diagnostic criteria for gestational diabetes in the real world: impact on health services, clinical care, and outcomes. Current Diabetes Reports. 2017;17(10):85–13.  https://doi.org/10.1007/s11892-017-0922-z.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Trujillo J, Vigo A, Duncan BB, Falavigna M, Wendland EM, Campos MA, et al. Impact of the International Association of Diabetes and Pregnancy Study Groups criteria for gestational diabetes. Diabetes Res Clin Pract. 2015;108(2):288–95.  https://doi.org/10.1016/j.diabres.2015.02.007.CrossRefPubMedGoogle Scholar
  43. 43.
    Hung TH, Hsieh TT. The effects of implementing the International Association of Diabetes and Pregnancy Study Groups criteria for diagnosing gestational diabetes on maternal and neonatal outcomes. PLoS One. 2015;10(3):e0122261.  https://doi.org/10.1371/journal.pone.0122261.CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    • Hosseini E, Janghorbani M. Systematic review and meta-analysis of diagnosing gestational diabetes mellitus with one-step or two-step approaches and associations with adverse pregnancy outcomes. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2018;143(2):137–44.  https://doi.org/10.1002/ijgo.12644. This meta-analysis study of 41,663 subjects from nine observational studies compared one-step and two-step (by Carpenter & Cousten criteria) approaches. It reported that women with GDM by both approaches were at increased risk for adverse pregnancy outcomes; though the associations with the two-step method were slightly stronger.CrossRefGoogle Scholar
  45. 45.
    Caissutti C, Khalifeh A, Saccone G, Berghella V. Are women positive for the one step but negative for the two step screening tests for gestational diabetes at higher risk for adverse outcomes? Acta Obstet Gynecol Scand. 2018;97(2):122–34.  https://doi.org/10.1111/aogs.13254.CrossRefPubMedGoogle Scholar
  46. 46.
    Mission JF, Ohno MS, Cheng YW, Caughey AB. Gestational diabetes screening with the new IADPSG guidelines: a cost-effectiveness analysis. American Journal of Obstetrics and Gynecology. 2012;207(4):326 e1–9.  https://doi.org/10.1016/j.ajog.2012.06.048.CrossRefPubMedGoogle Scholar
  47. 47.
    Coop C, Edlin R, Brown J, Farquhar C. Cost-effectiveness of the New Zealand diabetes in pregnancy guideline screening recommendations. BMJ Open. 2015;5(6):e006996.  https://doi.org/10.1136/bmjopen-2014-006996.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Sevket O, Ates S, Uysal O, Molla T, Dansuk R, Kelekci S. To evaluate the prevalence and clinical outcomes using a one-step method versus a two-step method to screen gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2014;27(1):36–41.  https://doi.org/10.3109/14767058.2013.799656.CrossRefPubMedGoogle Scholar
  49. 49.
    • Saccone G, Caissutti C, Khalifeh A, Meltzer S, Scifres C, Simhan HN, et al. One step versus two step approach for gestational diabetes screening: systematic review and meta-analysis of the randomized trials. The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2019;32(9):1547–55.  https://doi.org/10.1080/14767058.2017.1408068. This meta-analysis study of RCT found that one-step approach was associated with better maternal and perinatal outcomes, compared to two-step approach. However, only three RCTs were included in this meta-analysis and there were some limitations in these trials. CrossRefGoogle Scholar
  50. 50.
    Robitaille J. Excessive gestational weight gain and gestational diabetes: importance of the first weeks of pregnancy. Diabetologia. 2015;58(10):2203–5.  https://doi.org/10.1007/s00125-015-3725-2.CrossRefPubMedGoogle Scholar
  51. 51.
    Scifres CM, Abebe KZ, Jones KA, Comer DM, Costacou T, Freiberg MS, et al. Gestational diabetes diagnostic methods (GD2M) pilot randomized trial. Matern Child Health J. 2015;19(7):1472–80.  https://doi.org/10.1007/s10995-014-1651-4.CrossRefPubMedGoogle Scholar
  52. 52.
    • Khalifeh A, Eckler R, Felder L, Saccone G, Caissutti C, Berghella V. One-step versus two-step diagnostic testing for gestational diabetes: a randomized controlled trial. J Mater-Fetal Neonatal Med. 2018;1–6.  https://doi.org/10.1080/14767058.2018.1498480. This randomized controlled trial (RCT) of 249 pregnant women compared one-step and two-step strategies in the diagnosis of GDM. It showed that GDM incidence and adverse pregnancy events rate were not significantly different. However, the study was not adequately powered.
  53. 53.
    •• Abebe KZ, Scifres C, Simhan HN, Day N, Catalano P, Bodnar LM, et al. Comparison of Two Screening Strategies for Gestational Diabetes (GDM(2)) Trial: Design and rationale. Contemp Clin Trials. 2017;62:43–9.  https://doi.org/10.1016/j.cct.2017.08.012. An ongoing RCT for the comparison of one-step and two-step diagnostic strategies, which will be completed by the end of 2019. CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Lavery JA, Friedman AM, Keyes KM, Wright JD, Ananth CV. Gestational diabetes in the United States: temporal changes in prevalence rates between 1979 and 2010. BJOG : an International Journal of Obstetrics and Gynaecology. 2017;124(5):804–13.  https://doi.org/10.1111/1471-0528.14236.CrossRefGoogle Scholar
  55. 55.
    Jovanovič L, Liang Y, Weng W, Hamilton M, Chen L, Wintfeld N. Trends in the incidence of diabetes, its clinical sequelae, and associated costs in pregnancy. Diabetes Metab Res Rev. 2015;31(7):707–16.  https://doi.org/10.1002/dmrr.2656.CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Seshiah V, Balaji V, Balaji MS, Paneerselvam A, Arthi T, Thamizharasi M, et al. Gestational diabetes mellitus manifests in all trimesters of pregnancy. Diabetes Res Clin Pract. 2007;77(3):482–4.  https://doi.org/10.1016/j.diabres.2007.01.001.CrossRefPubMedGoogle Scholar
  57. 57.
    Schaefer-Graf UM, Buchanan TA, Xiang A, Songster G, Montoro M, Kjos SL. Patterns of congenital anomalies and relationship to initial maternal fasting glucose levels in pregnancies complicated by type 2 and gestational diabetes. Am J Obstet Gynecol. 2000;182(2):313–20.CrossRefGoogle Scholar
  58. 58.
    Riskin-Mashiah S, Younes G, Damti A, Auslender R. First-trimester fasting hyperglycemia and adverse pregnancy outcomes. Diabetes Care. 2009;32(9):1639–43.  https://doi.org/10.2337/dc09-0688.CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Farrar D, Simmonds M, Bryant M, Lawlor DA, Dunne F, Tuffnell D, et al. Risk factor screening to identify women requiring oral glucose tolerance testing to diagnose gestational diabetes: a systematic review and meta-analysis and analysis of two pregnancy cohorts. PLoS One. 2017;12(4):–e0175288.  https://doi.org/10.1371/journal.pone.0175288.CrossRefGoogle Scholar
  60. 60.
    Harrison CL, Lombard CB, East C, Boyle J, Teede HJ. Risk stratification in early pregnancy for women at increased risk of gestational diabetes. Diabetes Res Clin Pract. 2015;107(1):61–8.  https://doi.org/10.1016/j.diabres.2014.09.006.CrossRefPubMedGoogle Scholar
  61. 61.
    Jovanovic L, Metzger BE, Knopp RH, Conley MR, Park E, Lee YJ, et al. The Diabetes in Early Pregnancy Study: beta-hydroxybutyrate levels in type 1 diabetic pregnancy compared with normal pregnancy. NICHD-Diabetes in Early Pregnancy Study Group (DIEP). National Institute of Child Health and Development. Diabetes Care. 1998;21(11):1978–84.  https://doi.org/10.2337/diacare.21.11.1978.CrossRefPubMedGoogle Scholar
  62. 62.
    Zhu WW, Yang HX, Wei YM, Yan J, Wang ZL, Li XL, et al. Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in China. Diabetes Care. 2013;36(3):586–90.  https://doi.org/10.2337/dc12-1157.CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Yeral MI, Ozgu-Erdinc AS, Uygur D, Seckin KD, Karsli MF, Danisman AN. Prediction of gestational diabetes mellitus in the first trimester, comparison of fasting plasma glucose, two-step and one-step methods: a prospective randomized controlled trial. Endocrine. 2014;46(3):512–8.  https://doi.org/10.1007/s12020-013-0111-z.CrossRefPubMedGoogle Scholar
  64. 64.
    Benaiges D, Flores-Le Roux JA, Marcelo I, Mañé L, Rodríguez M, Navarro X, et al. Is first-trimester HbA1c useful in the diagnosis of gestational diabetes? Diabetes Res Clin Pract. 2017;133:85–91.  https://doi.org/10.1016/j.diabres.2017.08.019.CrossRefPubMedGoogle Scholar
  65. 65.
    •• Cosson E, Vicaut E, Sandre-Banon D, Gary F, Pharisien I, Portal JJ, et al. Early screening for gestational diabetes mellitus is not associated with improved pregnancy outcomes: an observational study including 9795 women. Diabetes & Metabolism. 2018.  https://doi.org/10.1016/j.diabet.2018.11.006. This observational study in 9,795 pregnant women found that early screening for GDM is not associated with improved pregnancy outcomes. CrossRefGoogle Scholar
  66. 66.
    •• Simmons D, Hague WM, Teede HJ, Cheung NW, Hibbert EJ, Nolan CJ, et al. Hyperglycaemia in early pregnancy: the Treatment of Booking Gestational diabetes Mellitus (TOBOGM) study. A randomised controlled trial. The Medical Journal of Australia. 2018;209(9):405–6. This large-scale multi-center RCT will assess the benefits of early screening and management of GDM. CrossRefGoogle Scholar
  67. 67.
    Agarwal MM, Dhatt GS, Shah SM. Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose. Diabetes Care. 2010;33(9):2018–20.  https://doi.org/10.2337/dc10-0572.CrossRefPubMedPubMedCentralGoogle Scholar
  68. 68.
    Trujillo J, Vigo A, Reichelt A, Duncan BB, Schmidt MI. Fasting plasma glucose to avoid a full OGTT in the diagnosis of gestational diabetes. Diabetes Res Clin Pract. 2014;105(3):322–6.  https://doi.org/10.1016/j.diabres.2014.06.001.CrossRefPubMedGoogle Scholar
  69. 69.
    Anjalakshi C, Balaji V, Balaji MS, Ashalata S, Suganthi S, Arthi T, et al. A single test procedure to diagnose gestational diabetes mellitus. Acta Diabetol. 2009;46(1):51–4.  https://doi.org/10.1007/s00592-008-0060-9.CrossRefPubMedGoogle Scholar
  70. 70.
    Kuo CH, Chen SC, Fang CT, Nien FJ, Wu ET, Lin SY, et al. Screening gestational diabetes mellitus: the role of maternal age. PLoS One. 2017;12(3):e0173049.  https://doi.org/10.1371/journal.pone.0173049.CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Ryser Ruetschi J, Jornayvaz FR, Rivest R, Huhn EA, Irion O, Boulvain M. Fasting glycaemia to simplify screening for gestational diabetes. BJOG : an International Journal of Obstetrics and Gynaecology. 2016;123(13):2219–22.  https://doi.org/10.1111/1471-0528.13857.CrossRefGoogle Scholar
  72. 72.
    Herath M, Priyantha Weerarathna T, Umesha D. Is non fasting glucose challenge test sensitive enough to diagnose gestational diabetes mellitus? Int Arch Med. 2015;8.Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Internal MedicineFu Jen Catholic University Hospital, Fu Jen Catholic UniversityNew Taipei CityTaiwan
  2. 2.Department of Internal MedicineNational Taiwan University HospitalTaipeiTaiwan

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