Current Diabetes Reports

, 19:121 | Cite as

Updates from the Evidence Base Examining Association between Periodontal Disease and Type 2 Diabetes Mellitus: Current Status and Clinical Relevance

  • Ingrid Glurich
  • Amit AcharyaEmail author
Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Other Forms of Diabetes and Its Complications


Purpose of the Review

Epidemiological surveillance documents an escalating epidemic prevalence of both type 2 diabetes (T2DM) and periodontal disease (PD). The principal goals of this review are to: 1) re-examine the clinical significance of associations between PD and T2DM, based on strength of collective evidence as determined by systematic review and meta-analysis, and 2) review findings of the systematic reviews and meta-analyses in light of the current understanding of PD-associated pathophysiology and intersection with T2DM pathophysiology.

Recent Findings

Tooth loss predicts risk for chronic disease and mortality. PD is significantly associated with complications of diabetes, including retinopathy. Based on systematic reviews and meta-analyses, the adjunctive use of certain antibiotics enhances non-surgical periodontal treatment (NSPT) in patients with T2DM. Systematic reviews and meta-analyses support NSPT efficacy in achieving metabolic control.


Systematic reviews and meta-analyses support the association between PD and T2DM, albeit the effect size may be modest. PD-T2DM interactions have important clinical implications.


Periodontal disease Diabetes mellitus, type 2 Systematic reviews as topic Meta-analysis as topic Tooth loss Delivery of healthcare, Integrated 


Funding Information

This review was supported by grant funding from Delta Dental of Wisconsin.

Compliance with Ethical Standards

Conflict of Interest

Ingrid Glurich and Amit Acharya declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center for Oral and Systemic HealthMarshfield Clinic Research InstituteMarshfieldUSA

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