Current Diabetes Reports

, 18:140 | Cite as

Non-Diabetic Hyperglycemia in the Pediatric Age: Why, How, and When to Treat?

  • Valentina Fattorusso
  • Rosa Nugnes
  • Alberto Casertano
  • Giuliana Valerio
  • Enza MozzilloEmail author
  • Adriana Franzese
Pediatric Type 2 and Monogenic Diabetes (PS Zeitler and O Pinhas-Hamiel, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Pediatric Type 2 and Monogenic Diabetes


Purpose of review

Non-diabetic hyperglycemia (NDHY) is a pathological condition that is not yet well known. The aim of this review is to examine approaches for management of this condition.

Recent findings

While it is well known that persistent hyperglycemia in diabetes affects immune response and risk for diabetes-related micro- and macrovascular complications, little is known about the biological effects of transient NDHY, particularly in the pediatric age group.


Stress HY (SHY) is typically defined as blood glucose > 8.33 mmol/L (150 mg/dL) during physical stress, resolving spontaneously after dissipation of acute illness in patients without known diabetes. Based on the literature and clinical practice, two situations can be classified: (1) SHY1, which occurs during severe and prolonged illness and under serious life-threatening conditions, mainly in emergency situations and in resuscitation areas; and (2) SHY2, which occurs during acute illness, mainly in non-life-threatening conditions. Furthermore, (NDHY) among pediatric patients can be induced by drugs; the most frequent conditions are secondary to (1) steroid therapy and (2) antineoplastic/immunosuppressive therapy.


Non-diabetic hyperglycemia Stress hyperglycemia Drug-induced hyperglycemia Management 


Compliance with Ethical Standards

Conflict of Interest

Valentina Fattorusso, Rosa Nugnes, Alberto Casertano, Giuliana Valerio, Enza Mozzillo, and Adriana Franzese declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by the any of the authors.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Valentina Fattorusso
    • 1
  • Rosa Nugnes
    • 1
  • Alberto Casertano
    • 1
  • Giuliana Valerio
    • 2
  • Enza Mozzillo
    • 1
    Email author
  • Adriana Franzese
    • 1
  1. 1.Department of Translational Medical Science (DISMET), Section of PediatricsUniversity of Naples Federico IINaplesItaly
  2. 2.Department of Movement Sciences and WellbeingParthenope UniversityNaplesItaly

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