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Current Diabetes Reports

, 18:63 | Cite as

SGLT2 Inhibitors and Cardiovascular Outcomes: Current Perspectives and Future Potentials

  • Xiaoming Jia
  • Paras B. Mehta
  • Yumei Ye
  • Mahboob Alam
  • Yochai Birnbaum
  • Mandeep Bajaj
Therapies and New Technologies in the Treatment of Diabetes (M Pietropaolo, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Therapies and New Technologies in the Treatment of Diabetes

Abstract

Purpose of Review

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to exert benefit on cardiac outcomes. In this review, we provide updates on available clinical data, studies on potential mechanisms for the CV effects, as well as discuss potential clinical implications of these new findings.

Recent Findings

Since the publications of the EMPA-REG and CANVAS trials, large multi-national cohort studies have further shown the cardioprotective effects of SGLT2i. Moreover, new studies examining SGLT2i action on sodium-hydrogen exchanger proteins in both the heart and the kidney, on myocardial energetics and impact on inflammation and atherosclerosis continue to shed light on the multitude of pleotropic effects of these agents.

Summary

Though more data is needed to substantiate the safety and efficacy, SGLT2i should be considered as a valuable therapy to help reduce CV risk in patients with diabetes. Ultimately, SGLT2i may have utility in preventing progression to diabetes or providing CV protection in patients who do not have diabetes.

Keywords

SGLT2 inhibitor Type 2 diabetes Cardiovascular outcomes 

Notes

Compliance with Ethical Standards

Conflict of Interest

Xiaoming Jia, Paras B. Mehta, and Mahboob Alam declare that they have no conflict of interest.

Yumei Ye reports grants from AstraZeneca and Boehringer-Ingelheim.

Yochai Birnbaum reports grants from AstraZeneca and Boehringer-Ingelheim.

Mandeep Bajaj reports grants from Amylin, AstraZeneca, Boehringer-Ingelheim, Eli Lilly, Sanofi-Aventis, and Novo Nordisk.

Human and Animal Rights and Informed Consent

All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Xiaoming Jia
    • 1
  • Paras B. Mehta
    • 3
  • Yumei Ye
    • 2
  • Mahboob Alam
    • 1
  • Yochai Birnbaum
    • 1
  • Mandeep Bajaj
    • 3
  1. 1.The Section of CardiologyDepartment of Medicine, Baylor College of MedicineHoustonUSA
  2. 2.The Department of Biochemistry and Molecular BiologyUniversity of Texas Medical BranchGalvestonUSA
  3. 3.Endocrinology and Diabetes DivisionDepartment of Medicine, Baylor College of MedicineHoustonUSA

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