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Current Diabetes Reports

, 17:132 | Cite as

Persistent Organic Pollutants as Risk Factors for Obesity and Diabetes

  • Chunxue Yang
  • Alice Pik Shan Kong
  • Zongwei CaiEmail author
  • Arthur C.K. ChungEmail author
Diabetes Epidemiology (NM Maruthur, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Diabetes Epidemiology

Abstract

Purpose of review

The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms.

Recent findings

Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction. POPs are synthesized chemicals and are used widely in our daily life. These chemicals are resistant to degradation in chemical or biological processes, which enable them to exist in the environment persistently and to be bio-accumulated in animal and human tissue through the food chain. Increasingly, epidemiologic studies suggest a positive association between POPs and risk of developing diabetes.

Summary

Understanding the relationship of POPs with obesity and diabetes may shed light on preventive strategies for obesity and diabetes.

Keywords

persistent organic pollutants obesity diabetes metabolic diseases 

Notes

Acknowledgments

This work was supported by grants from Mr. Kwok Yat Wai and Madam Kwok Chung Bo Fun Graduate School Development Fund, Hong Kong Baptist University; National Natural Science Foundation of China (General Program 21577115 and 21477101); the Research Grant Council of Hong Kong (RGC GRF 463612 and 14104314, 12300114); Faculty Research Grants from the Hong Kong Baptist University (FRG2/15-16/067; FRG2/16-17/049); Hong Kong Health and Medical Research Fund (HMRF/ 03144376); and HKASO research grant 2015-16.

Compliance with Ethics Guidelines

Conflict of Interest

Chunxue Yang, Alice Pik Shan Kong, Zongwei Cai, and Arthur C.K. Chung declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Partner, State Key Laboratory of Environmental and Biological Analysis, and Department of ChemistryHong Kong Baptist UniversityKowloon TongChina
  2. 2.HKBU Institute for Research and Continuing EducationShenzhenChina
  3. 3.Department of Medicine and TherapeuticsThe Chinese University of Hong Kong, Prince of Wales HospitalHong KongChina
  4. 4.Li Ka Shing Institute of Health SciencesThe Chinese University of Hong Kong, Prince of Wales HospitalHong KongChina
  5. 5.Hong Kong Institute of Diabetes and ObesityThe Chinese University of Hong Kong, Prince of Wales HospitalHong KongChina

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