Are Eating Disorders Risk Factors for Type 2 Diabetes? A Systematic Review and Meta-analysis
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Eating disorders (ED) affect energy intake modifying body fat depots. Prior evidence suggests that binge eating disorder (BED) and bulimia nervosa (BN) could increase the risk for type 2 diabetes (T2D), while anorexia nervosa (AN) could reduce it.
Purpose of Review
A systematic review and meta-analysis were conducted to evaluate if ED are risk factors for T2D.
Ten studies were selected out of 1057 screened. Meta-analysis of six studies with T2D as outcome is reported. Among cross-sectional studies, both BED (OR 3.69, 95% CI [1.12–12.12]) and BN (OR 3.45 [1.92–6.1]) increased the risk of T2D, while AN was not associated with lower risk (OR 0.87 [0.40–1.88]). Cohort studies showed increased risk of T2D with BN (RR 1.7 [1.2–2.5]), and decreased risk with AN (RR 0.71 [0.52–0.98]), but for BED the association was less clear (OR 3.34 [0.85–13.12]). Limitations of studies and recommendations for future research are presented.
KeywordsDiabetes mellitus type 2 Bulimia nervosa Eating disorders Anorexia nervosa Binge eating disorder Night eating syndrome
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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