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Current Diabetes Reports

, 17:138 | Cite as

Are Eating Disorders Risk Factors for Type 2 Diabetes? A Systematic Review and Meta-analysis

  • Ramfis Nieto-Martínez
  • Juan P. González-Rivas
  • José R. Medina-Inojosa
  • Hermes Florez
Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Lifestyle Management to Reduce Diabetes/Cardiovascular Risk

Abstract

Recent Findings

Eating disorders (ED) affect energy intake modifying body fat depots. Prior evidence suggests that binge eating disorder (BED) and bulimia nervosa (BN) could increase the risk for type 2 diabetes (T2D), while anorexia nervosa (AN) could reduce it.

Purpose of Review

A systematic review and meta-analysis were conducted to evaluate if ED are risk factors for T2D.

Summary

Ten studies were selected out of 1057 screened. Meta-analysis of six studies with T2D as outcome is reported. Among cross-sectional studies, both BED (OR 3.69, 95% CI [1.12–12.12]) and BN (OR 3.45 [1.92–6.1]) increased the risk of T2D, while AN was not associated with lower risk (OR 0.87 [0.40–1.88]). Cohort studies showed increased risk of T2D with BN (RR 1.7 [1.2–2.5]), and decreased risk with AN (RR 0.71 [0.52–0.98]), but for BED the association was less clear (OR 3.34 [0.85–13.12]). Limitations of studies and recommendations for future research are presented.

Keywords

Diabetes mellitus type 2 Bulimia nervosa Eating disorders Anorexia nervosa Binge eating disorder Night eating syndrome 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

11892_2017_949_MOESM1_ESM.docx (26 kb)
ESM 1 (DOCX 26 kb)

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    NCD-RisC, Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. (González-Rivas J.; Nieto-Martínez, R.; study group members). Lancet, 2016. 387(10027): p. 1513–30. doi: https://doi.org/10.1016/s0140-6736(16)00618-8.
  2. 2.
    Diagnostic and Statistical Manual of Mental Disorders, Fifth edition. Arlington, American Psychiatric Association, 2013.Google Scholar
  3. 3.
    Fairburn CG, Cooper Z. Eating disorders, DSM-5 and clinical reality. Br J Psychiatry. 2011;198(1):8–10.  https://doi.org/10.1192/bjp.bp.110.083881.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Olguin P, Fuentes M, Gabler G, Guerdjikova AI, Keck PE Jr, McElroy SL. Medical comorbidity of binge eating disorder. Eat Weight Disord. 2016;  https://doi.org/10.1007/s40519-016-0313-5.
  5. 5.
    Kessler RC, Berglund PA, Chiu WT, Deitz AC, Hudson JI, Shahly V, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73(9):904–14.  https://doi.org/10.1016/j.biopsych.2012.11.020.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 2000.Google Scholar
  7. 7.
    Duncan AE, Ziobrowski HN, Nicol G. The prevalence of past 12-month and lifetime DSM-IV eating disorders by BMI category in US men and women. Eur Eat Disord Rev. 2017;25(3):165–71.  https://doi.org/10.1002/erv.2503.CrossRefPubMedGoogle Scholar
  8. 8.
    Webb JB, Applegate KL, Grant JP. A comparative analysis of type 2 diabetes and binge eating disorder in a bariatric sample. Eat Behav. 2011;12(3):175–81.  https://doi.org/10.1016/j.eatbeh.2011.04.007.CrossRefPubMedGoogle Scholar
  9. 9.
    Meneghini LF, Spadola J, Florez H. Prevalence and associations of binge eating disorder in a multiethnic population with type 2 diabetes. Diabetes Care. 2006;29(12):2760.  https://doi.org/10.2337/dc06-1364.CrossRefPubMedGoogle Scholar
  10. 10.
    Crow S, Kendall D, Praus B, Thuras P. Binge eating and other psychopathology in patients with type II diabetes mellitus. Int J Eat Disord. 2001;30(2):222–6.CrossRefPubMedGoogle Scholar
  11. 11.
    Mannucci E, Tesi F, Ricca V, Pierazzuoli E, Barciulli E, Moretti S, et al. Eating behavior in obese patients with and without type 2 diabetes mellitus. Int J Obes Relat Metab Disord. 2002;26(6):848–53.  https://doi.org/10.1038/sj.ijo.0801976. CrossRefPubMedGoogle Scholar
  12. 12.
    Allison KC, Crow SJ, Reeves RR, West DS, Foreyt JP, Dilillo VG, et al. Binge eating disorder and night eating syndrome in adults with type 2 diabetes. Obesity (Silver Spring). 2007;15(5):1287–93.  https://doi.org/10.1038/oby.2007.150.CrossRefPubMedCentralGoogle Scholar
  13. 13.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Association; 2013.CrossRefGoogle Scholar
  14. 14.
    O’Reardon JP, Ringel BL, Dinges DF, Allison KC, Rogers NL, Martino NS, et al. Circadian eating and sleeping patterns in the night eating syndrome. Obes Res. 2004;12(11):1789–96.  https://doi.org/10.1038/oby.2004.222.CrossRefPubMedGoogle Scholar
  15. 15.
    Rand CS, Macgregor AM, Stunkard AJ. The night eating syndrome in the general population and among postoperative obesity surgery patients. Int J Eat Disord. 1997;22(1):65–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Smink FR, van Hoeken D, Hoek HW. Epidemiology of eating disorders: incidence, prevalence and mortality rates. Curr Psychiatry Rep. 2012;14(4):406–14.  https://doi.org/10.1007/s11920-012-0282-y.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007;61(3):348–58.  https://doi.org/10.1016/j.biopsych.2006.03.040.CrossRefPubMedGoogle Scholar
  18. 18.
    Preti A, Girolamo G, Vilagut G, Alonso J, Graaf R, Bruffaerts R, et al. The epidemiology of eating disorders in six European countries: results of the ESEMeD-WMH project. J Psychiatr Res. 2009;43(14):1125–32.  https://doi.org/10.1016/j.jpsychires.2009.04.003.CrossRefPubMedGoogle Scholar
  19. 19.
    Kenardy J, Mensch M, Bowen K, Green B, Walton J, Dalton M. Disordered eating behaviours in women with type 2 diabetes mellitus. Eat Behav. 2001;2(2):183–92.CrossRefPubMedGoogle Scholar
  20. 20.
    Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393–403.CrossRefPubMedGoogle Scholar
  21. 21.
    Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343–50.CrossRefPubMedGoogle Scholar
  22. 22.
    Pan XR, Li GW, YH H, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537–44.CrossRefPubMedGoogle Scholar
  23. 23.
    Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V. The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 2006;49:289–97.CrossRefPubMedGoogle Scholar
  24. 24.
    Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336–41.  https://doi.org/10.1016/j.ijsu.2010.02.007.CrossRefPubMedGoogle Scholar
  25. 25.
    Wells GA, Shea B, O’Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed 1 Nov 2016.
  26. 26.
    Johnson JG, Spitzer RL, Williams JB. Health problems, impairment and illnesses associated with bulimia nervosa and binge eating disorder among primary care and obstetric gynaecology patients. Psychol Med. 2001;31(8):1455–66.CrossRefPubMedGoogle Scholar
  27. 27.
    Bulik CM, Sullivan PF, Kendler KS. Medical and psychiatric morbidity in obese women with and without binge eating. Int J Eat Disord. 2002;32(1):72–8.  https://doi.org/10.1002/eat.10072.CrossRefPubMedGoogle Scholar
  28. 28.
    • de Jonge P, Alonso J, Stein DJ, Kiejna A, Aguilar-Gaxiola S, Viana MC, et al. Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. Diabetologia. 2014;57(4):699–709.  https://doi.org/10.1007/s00125-013-3157-9. Although with some limitations, this is the largest population-based multinational evaluation assessing ED and T2D, and included 52,095 adults from 19 countries. Both BED and BN increased the risk of T2D.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Mitchell JE, King WC, Pories W, Wolfe B, Flum DR, Spaniolas K, et al. Binge eating disorder and medical comorbidities in bariatric surgery candidates. Int J Eat Disord. 2015;48(5):471–6.  https://doi.org/10.1002/eat.22389.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Kenardy J, Mensch M, Bowen K, Pearson SAA. Comparison of eating behaviors in newly diagnosed NIDDM patients and case-matched control subjects. Diabetes Care. 1994;17(10):1197–9.CrossRefPubMedGoogle Scholar
  31. 31.
    Saucedo-Molina T, Villalon L, Zaragoza-Cortes J, León Hernández R, Calderón Ramos Z. Disordered eating behaviors in Mexican patients with and without type 2 diabetes mellitus. Revista Mexicana de Trastornos Alimentarios. 2015;6(1):13–21.CrossRefGoogle Scholar
  32. 32.
    • Ji J, Sundquist J, Sundquist K. Association between anorexia nervosa and type 2 diabetes in Sweden: etiological clue for the primary prevention of type 2 diabetes. Endocr Res. 2016;41(4):310–6.  https://doi.org/10.3109/07435800.2016.1141948. A retrospective cohort (ranging a 46-year period) analysis of 17,135 subjects, showing lower risk of T2D in subjects with AN.CrossRefPubMedGoogle Scholar
  33. 33.
    Hudson JI, Lalonde JK, Coit CE, Tsuang MT, McElroy SL, Crow SJ, et al. Longitudinal study of the diagnosis of components of the metabolic syndrome in individuals with binge-eating disorder. Am J Clin Nutr. 2010;91(6):1568–73.  https://doi.org/10.3945/ajcn.2010.29203.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    •• Raevuori A, Suokas J, Haukka J, Gissler M, Linna M, Grainger M, et al. Highly increased risk of type 2 diabetes in patients with binge eating disorder and bulimia nervosa. Int J Eat Disord. 2015;48(6):555–62.  https://doi.org/10.1002/eat.22334. Of the large cohort studies, this is the one that most offers data to evaluate whether the ED (BED, BN, and AN) modify the risk of T2D. This study included data before beginning the treatment, information of new cases of T2D (incidence), and also the lifetime prevalence of T2D.CrossRefPubMedGoogle Scholar
  35. 35.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorder (4th edn) (DSM–IV). American Psychiatric Association, 1994.Google Scholar
  36. 36.
    Diagnostic and Statistical Manual of Mental Disorders, Third edition. Arlington, American Psychiatric Association, 1980.Google Scholar
  37. 37.
    Fairburn CG, Steel JM. Anorexia nervosa in diabetes mellitus. Br Med J. 1980;280(6224):1167–8.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Mannucci E, Bardini G, Ricca V, Tessi F, Piani F, Vannini R, et al. Eating attitudes and behaviour in patients with type II diabetes. Diab Nutr Metab. 1997;10:275–81.Google Scholar
  39. 39.
    Herpertz S, Wagener R, Albus C, Kocnar M, Wagner R. Best F et al. diabetes mellitus and eating disorders: a multicenter study on the comorbidity of the two diseases. J Psychosom Res. 1998;44(3–4):503–15.CrossRefPubMedGoogle Scholar
  40. 40.
    Duke AA, Begue L, Bell R, Eisenlohr-Moul T. Revisiting the serotonin-aggression relation in humans: a meta-analysis. Psychol Bull. 2013;139(5):1148–72.  https://doi.org/10.1037/a0031544.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Buydens-Branchey L, Branchey M, Hudson J, Fergeson P, Low HDL. Cholesterol, aggression and altered central serotonergic activity. Psychiatry Res. 2000;93(2):93–102.CrossRefPubMedGoogle Scholar
  42. 42.
    Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24(6):1069–78.CrossRefPubMedGoogle Scholar
  43. 43.
    Rosenblat JD, Cha DS, Mansur RB, McIntyre RS. Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 2014;53:23–34.  https://doi.org/10.1016/j.pnpbp.2014.01.013.CrossRefGoogle Scholar
  44. 44.
    Patel C, Ghanim H, Ravishankar S, Sia CL, Viswanathan P, Mohanty P, et al. Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab. 2007;92(11):4476–9.  https://doi.org/10.1210/jc.2007-0778.CrossRefPubMedGoogle Scholar
  45. 45.
    Speakman JR, Mitchell SE. Caloric restriction. Mol Asp Med. 2011;32(3):159–221.  https://doi.org/10.1016/j.mam.2011.07.001.CrossRefGoogle Scholar
  46. 46.
    Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res : J Lab Clin Med. 2014;164(4):302–11.  https://doi.org/10.1016/j.trsl.2014.05.013. CrossRefGoogle Scholar
  47. 47.
    Young-Hyman DL, Davis CL. Disordered eating behavior in individuals with diabetes: importance of context, evaluation, and classification. Diabetes Care. 2010;33(3):683–9.  https://doi.org/10.2337/dc08-1077.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Ramfis Nieto-Martínez
    • 1
    • 2
    • 3
  • Juan P. González-Rivas
    • 4
  • José R. Medina-Inojosa
    • 5
  • Hermes Florez
    • 1
    • 6
  1. 1.Geriatric Research, Education, and Clinical Center (GRECC) and South Florida Veterans Affairs Foundation for Research & EducationMiami VA Healthcare SystemMiamiUSA
  2. 2.Department of Physiology, School of MedicineUniversity Centro-Occidental “Lisandro Alvarado” and Cardio-metabolic Unit 7BarquisimetoVenezuela
  3. 3.Miami Veterans Affairs Medical CenterMiamiUSA
  4. 4.The Andes Clinic of Cardio-Metabolic StudiesMéridaVenezuela
  5. 5.Division of Preventive Cardiology, Department of Cardiovascular Medicine. Mayo ClinicRochesterUSA
  6. 6.Departments of Public Health Sciences and MedicineUniversity of Miami Miller School of MedicineMiamiUSA

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