Current Diabetes Reports

, 16:8 | Cite as

Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance

Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatric Type 2 Diabetes


Pediatricians increasingly diagnose the metabolic syndrome (MetS) in recent years to describe cardiovascular risk and to guide management of the obese child. However, there is an ongoing discussion about how to define the MetS in childhood and adolescence. Since insulin resistance—the major driver of MetS—is influenced by pubertal stage, it is questionable to use definitions for MetS in children and adolescents that do not take into account pubertal status. A metabolic healthy status in prepubertal stage does not predict a metabolic healthy status during puberty. Furthermore, cardiovascular risk factors improve at the end of puberty without treatment. However, having a uniform internationally accepted definition of the MetS for children and adolescents would be very helpful for the description of populations in different studies. Therefore, the concept of MetS has to be revisited under the influence of puberty stage.


Puberty Definition Metabolic Syndrome Intervention Obesity 


Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Children’s HospitalUniversity of Witten/HerdeckeDattelnGermany

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