Ambient Air Pollution: An Emerging Risk Factor for Diabetes Mellitus
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Growing evidence supports that air pollution has become an important risk factor for developing diabetes mellitus. Understanding the contributing effect of air pollution in population studies, elucidating the potential mechanisms involved, and identifying the most responsible pollutants are all required in order to promulgate successful changes in policy and to help formulate preventive measures in an effort to reduce the risk for diabetes. This review summarizes recent findings from epidemiologic studies and mechanistic insights that provide links between exposure to air pollution and a heightened risk for diabetes.
KeywordsInsulin resistance Particulate matter Metabolic syndrome Obesity
This work was supported by the United States Environmental Protection Agency grant RD83479701 (S. Rajagopalan and R. Brook) and R01ES015146-06, R01ES019616-04, and R01ES017290-05 (S. Rajagopalan). J. Montresor-Lopez’ and R. Puett’s work was partially supported by grant R01ES019168 from the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIEHS, NIH. The authors acknowledge Jessica Green-Barnes for her assistance with tables.
Compliance with Ethics Guidelines
Conflict of Interest
Xiaoquan Rao, Jessica Montresor-Lopez, Robin Puett, Sanjay Rajagopalan, and Robert D. Brook declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
No original research was performed for or presented in this review paper. Therefore, this article does not contain any studies with human or animal subjects performed by any of the authors. With regard to the authors’ human research cited in this paper, all procedures were followed in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000 and 2008. With regard to the authors’ animal study cited in this paper, all applicable international, national, and/or institutional guidelines for the care and use of animals were followed.
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