Current Diabetes Reports

, 15:566 | Cite as

Morbidity and Mortality in Young-Onset Type 2 Diabetes in Comparison to Type 1 Diabetes: Where Are We Now?

  • Jencia Wong
  • Maria Constantino
  • Dennis K. Yue
Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatric Type 2 Diabetes


Increasingly, we recognise that type 2 diabetes in youth is a disease with an aggressive time course and a significant complication risk. On the other hand, outcomes for youth with type 1 diabetes appear generally to be improving. With increasing numbers of both types of diabetes in youth, it is timely that a comparative perspective is offered to help clinicians prognosticate more appropriately. Contemporary comparative studies add a new perspective to a consistent story, that for youth-onset type 2 diabetes, the development and progression of cardio-renal complications are increased and the survival prognosis is significantly worse than for type 1 diabetes. Here, we review this mounting evidence, highlight the importance of metabolic syndrome factors in the excess risk and underscore that there remains a significant mortality gap for youth with either type of diabetes, to be addressed as a matter of urgency.


Diabetes mellitus Type 1 diabetes Type 2 diabetes Youth Mortality Diabetes complications 


Compliance with Ethics Guidelines

Conflict of Interest

Jencia Wong, Maria Constantino and Dennis Yue declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jencia Wong
    • 1
    • 2
  • Maria Constantino
    • 1
    • 2
  • Dennis K. Yue
    • 1
    • 2
  1. 1.Royal Prince Alfred Hospital Diabetes CentreSydneyAustralia
  2. 2.Sydney Medical SchoolUniversity of SydneySydneyAustralia

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