Current Diabetes Reports

, 14:517 | Cite as

Type 1 Diabetes and Celiac Disease: Clinical Overlap and New Insights into Disease Pathogenesis

  • Aaron Cohn
  • Anthony M. Sofia
  • Sonia S. KupferEmail author
Diabetes and Other Diseases-Emerging Associations (JJ Nolan, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Diabetes and Other Diseases—Emerging Associations


Type 1 diabetes (T1D) and celiac disease (CD) are autoimmune diseases with clinical and pathogenic overlap. The mean prevalence of CD in patients with T1D is about 8 %. Classic intestinal symptoms of CD may not be present in T1D leading to the recommendation for active case finding in this higher risk group. Screening is done with sensitive and specific serologies including tissue transglutaminase (tTG) IgA and deaminated gliadin peptide (DGP) IgA and IgG. Positive serologies are confirmed by the presence of villous atrophy and increased intraepithelial lymphocytes on duodenal biopsy. A strict gluten free diet is recommended, although this can pose challenges for T1D patients who already have dietary restrictions. In aggregate, it appears as if the gluten free diet may help T1D management. T1D and CD have overlapping genetic and environmental risk factors. Among these, non-HLA genetic factors and the gut microbiome are among recent developments that will be discussed in this review.


Type 1 diabetes Celiac disease HLA genetics Microbiome 


Compliance with Ethics Guidelines

Conflict of Interest

Aaron Cohn, M. Anthony Sofia, and Sonia S. Kupfer declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Aaron Cohn
    • 1
  • Anthony M. Sofia
    • 1
  • Sonia S. Kupfer
    • 1
    Email author
  1. 1.Department of MedicineUniversity of ChicagoChicagoUSA

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