Current Diabetes Reports

, 14:516

Resistant Hypertension in Diabetes Mellitus

  • George Bayliss
  • Larry A. Weinrauch
  • John A. D’Elia
Microvascular Complications—Nephropathy (B Roshan, Section Editor)

DOI: 10.1007/s11892-014-0516-y

Cite this article as:
Bayliss, G., Weinrauch, L.A. & D’Elia, J.A. Curr Diab Rep (2014) 14: 516. doi:10.1007/s11892-014-0516-y
Part of the following topical collections:
  1. Topical Collection on Microvascular Complications—Nephropathy

Abstract

Resistant hypertension in diabetes is associated with poor cardiovascular and renal outcomes. This brief review will examine the definitions and epidemiology of resistant hypertension and consider the differences between apparent resistant hypertension and truly resistant or refractory hypertension. It will review the role of the sympathetic nervous system in resistant hypertension. It will consider the relationship between obesity and leptin resistance and sympathetic signaling; the role of obstructive sleep apnea in resistant hypertension; and the role of aldosterone in resistant hypertension. It will conclude by mentioning briefly renal nerve ablation.

Keywords

Resistant hypertension Sympathetic nervous system Leptin Aldosterone Diabetes mellitus 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • George Bayliss
    • 1
    • 2
  • Larry A. Weinrauch
    • 3
    • 4
  • John A. D’Elia
    • 3
    • 4
  1. 1.Division of Kidney Diseases and HypertensionRhode Island HospitalProvidenceUSA
  2. 2.Alpert Medical SchoolBrown UniversityProvidenceUSA
  3. 3.Joslin Diabetes Center and Beth Israel Deaconess Medical CenterBostonUSA
  4. 4.Harvard Medical SchoolBostonUSA

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