Is There an Effect of Glucose Lowering Treatment on Incidence and Prognosis of Tuberculosis? A Systematic Review

Diabetes and Other Diseases-Emerging Associations (JJ Nolan, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Diabetes and Other Diseases—Emerging Associations

Abstract

The association between diabetes and incidence of tuberculosis is well established, and observational studies have shown poor treatment outcome in tuberculosis related to hyperglycemia. The WHO recommends screening for diabetes among all patients with tuberculosis and optimized glycemic control aiming at improving tuberculosis outcome. However, no intervention studies support this notion. Patients with tuberculosis are often vulnerable with high degree of comorbidity, and, therefore, at high risk of adverse effects of intensive glucose control. Controlled intervention studies of the effect of glucose lowering treatment on tuberculosis outcomes are clearly warranted to justify screening for- and tight control of diabetes.

Keywords

Diabetes Glycemic control Tuberculosis incidence Tuberculosis outcome Glucose lowering treatment 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Marit Eika Jørgensen is employed by Steno Diabetes Center, a research hospital working in the Danish National Health Service and owned by Novo Nordisk A/S.

Daniel Faurholt-Jepsen declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

11892_2014_505_MOESM1_ESM.docx (73 kb)
ESM 1 (DOCX 73 kb)

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Marit Eika Jørgensen
    • 1
  • Daniel Faurholt-Jepsen
    • 2
    • 3
  1. 1.Steno Diabetes CenterGentofteDenmark
  2. 2.Department of Nutrition, Exercise, and SportsUniversity of CopenhagenFrederiksbergDenmark
  3. 3.Department of Infectious DiseasesRigshospitaletCopenhagenDenmark

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