Risks and Benefits of Statin Use in Young People with Type 1 Diabetes

Macrovascular Complications in Diabetes (L Perreault, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Macrovascular Complications in Diabetes

Abstract

Cardiovascular disease (CVD) is the primary cause of mortality in patients with type 1 diabetes (T1D). Despite advances in the management of microvascular complications of T1D, there is a lack of similar progress in reduction of macrovascular complications. Dyslipidemia is one of the major contributory factors for macrovascular complications in T1D, but the literature suggests significant under-treatment of this risk factor in children and adolescents with diabetes. Statins have shown to be both effective and safe in young people with familial hypercholesterolemia and adults with diabetes mellitus, but the role for statins in children and adolescent with T1D remains unclear and controversial. In this review, we will summarize the risks and benefits of statin use in young people with T1D.

Keywords

Dyslipidemia Type 1 diabetes Statins Lipid-lowering medications Macrovascular complications Microvascular complications 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Petter Bjornstad and R. Paul Wadwa declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PediatricsUniversity of Colorado School of MedicineAuroraUSA
  2. 2.Barbara Davis Center for Childhood DiabetesUniversity of Colorado, DenverAuroraUSA

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