Cardiovascular Risk Stratification and Management in Pre-Diabetes

  • Kristine Færch
  • Dorte Vistisen
  • Nanna Borup Johansen
  • Marit Eika Jørgensen
Macrovascular Complications in Diabetes (L Perreault, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Macrovascular Complications in Diabetes


Prediabetes, covering individuals with impaired fasting glycemia, impaired glucose tolerance, or high-risk HbA1c levels, is associated with a ∼20 % increased risk of developing cardiovascular disease (CVD) compared with normoglycemic individuals. It is well-known that lifestyle or pharmacologic interventions can prevent diabetes in prediabetic people; however, the evidence is less clear regarding prevention of CVD. Most diabetes prevention trials have failed to show beneficial effects on CVD morbidity and mortality despite significant improvements of CVD risk factors in individuals with prediabetes. Another challenge is how to estimate CVD risk in prediabetic people. In general, prediction models for CVD do not take glucose levels or prediabetes status into account, thereby underestimating CVD risk in these high-risk individuals. More evidence within risk stratification and management of CVD risk in prediabetes is needed in order to recommend useful and effective strategies for early prevention of CVD.


Prediabetes Impaired fasting glucose Impaired glucose tolerance Fasting glucose 2-hour glucose HbA1c Cardiovascular disease Risk prediction Risk stratification Prevention Management 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kristine Færch
    • 1
  • Dorte Vistisen
    • 1
  • Nanna Borup Johansen
    • 1
  • Marit Eika Jørgensen
    • 1
  1. 1.Steno Diabetes Center A/SNiels Steensens Vej 2GentofteDenmark

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