Current Diabetes Reports

, 14:491

Diabetes and Depression

  • Richard I. G. Holt
  • Mary de Groot
  • Sherita Hill Golden
Diabetes and Other Diseases-Emerging Associations (JJ Nolan, Section Editor)

DOI: 10.1007/s11892-014-0491-3

Cite this article as:
Holt, R.I.G., de Groot, M. & Golden, S.H. Curr Diab Rep (2014) 14: 491. doi:10.1007/s11892-014-0491-3
Part of the following topical collections:
  1. Topical Collection on Diabetes and Other Diseases—Emerging Associations


Diabetes and depression occur together approximately twice as frequently as would be predicted by chance alone. Comorbid diabetes and depression are a major clinical challenge as the outcomes of both conditions are worsened by the other. Although the psychological burden of diabetes may contribute to depression, this explanation does not fully explain the relationship between these 2 conditions. Both conditions may be driven by shared underlying biological and behavioral mechanisms, such as hypothalamic-pituitary-adrenal axis activation, inflammation, sleep disturbance, inactive lifestyle, poor dietary habits, and environmental and cultural risk factors. Depression is frequently missed in people with diabetes despite effective screening tools being available. Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control. Clear care pathways involving a multidisciplinary team are needed to obtain optimal medical and psychiatric outcomes for people with comorbid diabetes and depression.


Depression Diabetes Screening Treatment Mechanisms 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Richard I. G. Holt
    • 1
  • Mary de Groot
    • 2
  • Sherita Hill Golden
    • 3
  1. 1.Human Development and Health Academic Unit, Faculty of Medicine, The Institute of Developmental Sciences (IDS Building), MP887, Southampton General HospitalUniversity of SouthamptonSouthamptonUK
  2. 2.Department of Medicine and the Diabetes Translational Research CenterIndiana University School of MedicineIndianapolisUSA
  3. 3.Departments of Medicine and EpidemiologyJohns Hopkins University Schools of Medicine and Public HealthBaltimoreUSA

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