Current Diabetes Reports

, Volume 13, Issue 5, pp 616–623

Antigen-Based Vaccination and Prevention of Type 1 Diabetes

  • Leonard C. Harrison
  • John M. Wentworth
  • Yuxia Zhang
  • Esther Bandala-Sanchez
  • Ralph M. Böhmer
  • Alana M. Neale
  • Natalie L. Stone
  • Gaetano Naselli
  • Julian J. Bosco
  • Priscilla Auyeung
  • Maryam Rashidi
  • Petra Augstein
  • Grant Morahan
Pathogenesis of Type 1 Diabetes (D Dabelea, Section Editor)

DOI: 10.1007/s11892-013-0415-7

Cite this article as:
Harrison, L.C., Wentworth, J.M., Zhang, Y. et al. Curr Diab Rep (2013) 13: 616. doi:10.1007/s11892-013-0415-7

Abstract

Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle–dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.

Keywords

Autoimmune Type 1 diabetes Islet β cell Preclinical Autoantibody T cell Regulation Prediction Prevention Vaccination Insulin GAD65 Mucosa Nasal Oral Immune Suppression Tolerance Clinical trial Antigen 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Leonard C. Harrison
    • 1
  • John M. Wentworth
    • 1
  • Yuxia Zhang
    • 1
  • Esther Bandala-Sanchez
    • 1
  • Ralph M. Böhmer
    • 1
  • Alana M. Neale
    • 1
  • Natalie L. Stone
    • 1
  • Gaetano Naselli
    • 1
  • Julian J. Bosco
    • 1
  • Priscilla Auyeung
    • 1
  • Maryam Rashidi
    • 1
  • Petra Augstein
    • 1
  • Grant Morahan
    • 1
  1. 1.Walter & Eliza Hall Institute of Medical ResearchParkvilleAustralia

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