Current Diabetes Reports

, Volume 13, Issue 5, pp 745–755

Bioengineered Sites for Islet Cell Transplantation

Transplantation (A Pileggi, Section Editor)

DOI: 10.1007/s11892-013-0412-x

Cite this article as:
Vériter, S., Gianello, P. & Dufrane, D. Curr Diab Rep (2013) 13: 745. doi:10.1007/s11892-013-0412-x

Abstract

Although islet transplantation has demonstrated its potential use in treating type 1 diabetes, this remains limited by the need for daily immunosuppression. Islet encapsulation was then proposed with a view to avoiding any immunosuppressive regimen and related side effects. In order to obtain a standard clinical procedure in terms of safety and reproducibility, two important factors have to be taken into account: the encapsulation design (which determines the graft volume) and the implantation site. Indeed, the implantation site should meet certain requirements: (1) its space must be large enough for the volume of transplanted tissues; (2) there must be proximity to abundant vascularization with a good oxygen supply; (3) there must be real-time access to physiologically representative blood glucose levels; (4) there must be easy access for implantation and the reversibility of the procedure (for safety); and finally, (5) the site should have minimal early inflammatory reaction and promote long-term survival. The aim of this article is to review possible preclinical/clinical implantation sites (in comparison with free islets) for encapsulated islet transplantation as a function of the encapsulation design: macro/microcapsules and conformal coating.

Keywords

Islet cell transplantation Encapsulation Implantation site Bioengineered sites 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sophie Vériter
    • 1
  • Pierre Gianello
    • 2
  • Denis Dufrane
    • 1
  1. 1.Unité de thérapie cellulaire endocrine, Centre de thérapie tissulaire et cellulaireCliniques universitaires Saint LucBrusselsBelgium
  2. 2.Pôle de Chirurgie Expérimentale et Transplantation, Institut de Recherche Expérimentale et Clinique, Secteur des Sciences de la SantéUniversité catholique de LouvainBrusselsBelgium

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