Magnetic Resonance Imaging of the Central Nervous System in Diabetic Neuropathy
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Diabetic ‘peripheral’ neuropathy (DPN) is one of the common sequelae to the development of both type-1 and type-2 diabetes mellitus. Neuropathy has a major negative impact on quality of life. Abnormalities in both peripheral vasculature and nerve function are well documented and, in addition, evidence is emerging regarding changes within the central nervous system (CNS) that are concomitant with the presence of DPN. The often-resistant nature of DPN to medical treatment highlights the need to understand the role of the CNS in neuropathic symptomatology and progression, as this may modulate therapeutic approaches. Advanced neuroimaging techniques, especially those that can provide quantitative measures of structure and function, can provide objective markers of CNS status. With that comes great potential for not only furthering our understanding of involvement of the CNS in neuropathic etiology but also most importantly aiding the development of new and more effective, targeted, analgesic interventions.
KeywordsDiabetic peripheral neuropathy Neuroimaging Magnetic resonance imaging Brain Spine Central nervous system
Compliance with Ethics Guidelines
Conflict of Interest
Iain D. Wilkinson declares that he has no conflict of interest.
Dinesh Selvarajah declares that he has no conflict of interest.
Marni Greig declares that he has no conflict of interest.
Pallai Shillo declares that he has no conflict of interest.
Elaine Boland declares that she has no conflict of interest.
Rajiv Gandhi declares that he has no conflict of interest.
Solomon Tesfaye declares that he has no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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