Diabetes Mellitus and Inflammation
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Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.
KeywordsDiabetes mellitus Inflammation Biomarkers Adipocytes Cytokines Adipokines Interleukin
Conflict of Interest
Eric Lontchi-Yimagou declares that he has no conflict of interest.
Eugene Sobngwi declares that he has no conflict of interest.
Tandi E Matsha declares that she has no conflict of interest.
Andre Pascal Kengne declares that he has no conflict of interest.
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- 1.International Diabetes Federation. In: Unwin N, Whiting D, Guariguata L, Ghyoot G, Gan D, editors. Updated Diabetes Atlas 2011. 5th ed. Brussels; 2011.Google Scholar
- 12.Kengne AP, Czernichow S, Stamatakis E, et al. Fibrinogen and future cardiovascular disease in people with diabetes: aetiological associations and risk prediction using individual participant data from 9 community-based prospective cohort studies. Diabetes Vasc Dis Res. 2012.Google Scholar
- 19.Kiechl S, Wittmann J, Giaccari A, et al. Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013. doi: 10.1038/nm.3084
- 35.Pradhan S, Goel K. Interrelationship between diabetes and periodontitis: a review. J Nepal Med Assoc. 2011;51:144–53.Google Scholar
- 41.Liu C, Ying Z, Harkema J, et al. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicol Pathol. 2012. doi: 10.1177/0192623312464531
- 42.Khan H, Kunutsor S, Franco OH, Chowdhury R. Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies. Proc Nutr Soc. 2013;72:89–97.Google Scholar
- 48.Cruz NG, Sousa LP, Sousa MO, et al. The linkage between inflammation and Type 2 diabetes mellitus. Diabetes Res Clin Pract. 2012. doi: 10.1016/j.diabres.2012.09.003
- 54.•• Gkrania-Klotsas E, Ye Z, Cooper AJ, et al. Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One. 2010;5:e13405. This systematic review and meta-analysis based on a large number of studies and participants provides evidence supporting the association of total white cell counts and subfractions on type 2 diabetes risk.PubMedCrossRefGoogle Scholar
- 65.Rourke JL, Dranse HJ, Sinal CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease. Obes Rev. 2013;14:245–62.Google Scholar
- 74.Ye J, McGuinness OP. Inflammation during obesity is not all bad: Evidence from animal and human studies. Am J Physiol Endocrinol Metab. 2013;304:E466–77.Google Scholar
- 80.•• Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol. 2012;3:181. This paper provides an extensive and recent overview on signaling pathways linking obesity to insulin resistance.Google Scholar
- 93.• George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 2012;29:e142–50. This systematic review and meta-analysis showed that vitamin D supplementation had a small improvement effect on fasting glucose and insulin resistance among people with diabetes or impaired glucose tolerance, but no effect on glycated haemoglobin among those with diabetes.PubMedCrossRefGoogle Scholar
- 94.Panwar H, Rashmi HM, Batish VK, Grover S. Probiotics as the potential biotherapeutics in the management of Type 2 Diabetes—prospects and perspectives. Diabetes Metab Res Rev. 2013;29:103–12.Google Scholar