Current Diabetes Reports

, Volume 13, Issue 3, pp 435–444 | Cite as

Diabetes Mellitus and Inflammation

  • Eric Lontchi-Yimagou
  • Eugene Sobngwi
  • Tandi E. Matsha
  • Andre Pascal Kengne
Diabetes and Other Diseases—Emerging Associations (D Aron, Section Editor)

Abstract

Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.

Keywords

Diabetes mellitus Inflammation Biomarkers Adipocytes Cytokines Adipokines Interleukin 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Eric Lontchi-Yimagou
    • 1
  • Eugene Sobngwi
    • 2
    • 3
  • Tandi E. Matsha
    • 4
  • Andre Pascal Kengne
    • 5
    • 6
    • 7
  1. 1.Laboratory for Molecular and Metabolic Diseases, Biotechnology CenterUniversity of Yaoundé 1YaoundéCameroon
  2. 2.National Obesity CenterYaounde Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1YaoundéCameroon
  3. 3.Institute of Health and SocietyNewcastle UniversityNewcastleUK
  4. 4.Department of Biomedical Sciences, Faculty of Health and Wellness ScienceCape Peninsula University of TechnologyCape TownSouth Africa
  5. 5.South African Medical Research Council & University of Cape TownCape TownSouth Africa
  6. 6.The George Institute for Global HealthSydneyAustralia
  7. 7.Julius Center for Health Sciences and Primary CareUniversity Medical Center UtrechtUtrechtThe Netherlands

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