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Current Diabetes Reports

, Volume 13, Issue 3, pp 445–452 | Cite as

Diabetes Mellitus and Periodontal Diseases

  • Corneliu Sima
  • Michael Glogauer
Diabetes and Other Diseases—Emerging Associations (D Aron, Section Editor)

Abstract

A bidirectional relationship between diabetes mellitus (DM) and periodontal diseases (PDs) has been established. It is estimated that patients with poorly controlled DM are 3 times more likely to develop chronic PD compared with normoglycemic individuals despite similar composition in subgingival biofilms. Furthermore, these patients present with increased severity and rapid progression of attachment loss around teeth resulting in edentulism. Treatment of PD results in a modest but significant improvement in glycemic control in patients with DM reflected by a 0.4 % reduction in HbA1cglycated hemoglobin levels. Compelling evidence from in vitro and animal studies supports a plausible biological explanation for the relationship between the 2 conditions centered on systemic low-grade inflammation. However, the limited number of comparable large randomized clinical trials is reflected in the limited specific guidelines offered by the international organizations for DM and PD regarding the management of the 2 diseases in an individual.

Keywords

Diabetes mellitus Periodontal diseases Inflammation Glycemic control HbA1c 

Notes

Conflict of Interest

Corneliu Sima declares that he has no conflict of interest.

Michael Glogauer declares that he has no conflict of interest.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Matrix Dynamics GroupTorontoCanada
  2. 2.University of TorontoTorontoCanada

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