Current Diabetes Reports

, Volume 12, Issue 4, pp 440–446 | Cite as

Pathophysiology of Obesity-Related Renal Dysfunction Contributes to Diabetic Nephropathy

  • George BaylissEmail author
  • Larry A. Weinrauch
  • John A. D’Elia
Microvascular Complications—Nephropathy (B Roshan, Section Editor)


Recent studies have demonstrated the role of insulin resistance in renal injury related to obesity, with hyperfiltration leading to glomerulomegaly in a pattern similar to that found in diabetic nephropathy. Similarities in the histologic patterns of damage from obesity and diabetes point to overlapping mechanisms of injury. In this review, we will examine the hormonal mechanisms, signaling pathways and injury patterns in renal injury resulting from obesity and attempt to draw conclusions on the reasons for these similarities.


Obesity Obstructive sleep apnea Proteinuria Insulin resistance Podocyte Nephrin Adipocyte Diabetes Renal dysfunction Diabetic nephropathy 



The authors wish to thank Diane Young for her help in preparing this article.


Conflicts of interest: G. Bayliss: none; L.A. Weinrauch: none; J.A. D’Elia: has received grant support from the Pat Covelli Foundation, Amgen Corp., and Bayer Laboratories as investigator-initiated research.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • George Bayliss
    • 1
    • 2
    Email author
  • Larry A. Weinrauch
    • 3
  • John A. D’Elia
    • 3
    • 4
  1. 1.Division of Kidney Diseases and HypertensionRhode Island and Miriam HospitalsProvidenceUSA
  2. 2.Alpert Medical SchoolBrown UniversityProvidenceUSA
  3. 3.Harvard Medical SchoolBostonUSA
  4. 4.Renal Unit, Joslin Diabetes CenterBeth Israel Deaconess Medical CenterBostonUSA

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