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Who Should We Target for Diabetes Prevention and Diabetes Risk Reduction?

  • Translational Strategies for Diabetes Prevention (D Marrero, Section Editor)
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Abstract

Screening for individual diabetes risk is crucial to identify adult and pediatric high-risk target populations for referral into successful diabetes prevention programs. Determination of impaired glucose tolerance or elevated fasting glucose levels has been the “gold standard” to classify subjects at increased risk for and/or to diagnose type 2 diabetes (T2DM). However, this led to ignoring many individuals prone to develop the disease. Therefore, using a stepped strategy consisting of a preliminary assessment of risk factors, by using risk scores such as the Finnish Diabetes Risk Score (FINDRISC) adapted to the respective population, followed by a single blood test determining blood glucose or hemoglobin A1c, respectively, or an oral glucose tolerance test is a feasible and pragmatic method to more accurately detect individuals at risk for T2DM. Inclusion of further risk factors into the assessment such as physical inactivity, waist circumference, and prenatal factors needs to be thoroughly discussed to establish a valid and reliable stepped approach applicable to real world health care. This article provides an overview of the current literature and is intentionally focused on the identification of high-risk populations (both adult and pediatric) that will help to address the key issues around the prevention of T2DM in health care settings.

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Acknowledgment

This work was supported by the European Commission AGREEMENT NUMBER–2006309, the Federal Ministry of Education and Research (BMBF), Germany (IFB AdiposityDiseases, FKZ: 01EO1001, to SB, JM, SH), by the Roland-Ernst-Stiftung für Gesundheitsforschung Dresden, Germany (SB), and by the Saxonian State Ministry of Social Affairs Dresden, Germany (to SB). We also would like to thank the Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig (Head: Prof. W. Kiess).

Disclosure

Conflicts of interest: S. Blüher: none; J. Markert: none; S. Herget: none; T. Yates: none; M. Davis: none; G. Müller: none; T. Waldow: none; P.E.H. Schwarz: none.

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Authors and Affiliations

  1. Leipzig University Medical Center, IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany

    Susann Blüher, Jana Markert & Sabine Herget

  2. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK

    Thomas Yates & Melanie Davis

  3. Institute for Medical Informatics, Technische Universität Dresden, Dresden, Germany

    Gabriele Müller

  4. Department of Cardio Surgery, Technische Universität Dresden, Dresden, Germany

    Thomas Waldow

  5. Division for Prevention and Care of Diabetes Mellitus, Technische Universität Dresden, Dresden, Germany

    Peter E. H. Schwarz

  6. Abteilung Prävention und Versorgung des Diabetes, Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany

    Peter E. H. Schwarz

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  1. Susann Blüher
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  8. Peter E. H. Schwarz
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Correspondence to Peter E. H. Schwarz.

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Blüher, S., Markert, J., Herget, S. et al. Who Should We Target for Diabetes Prevention and Diabetes Risk Reduction?. Curr Diab Rep 12, 147–156 (2012). https://doi.org/10.1007/s11892-012-0255-x

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