Current Diabetes Reports

, Volume 11, Issue 1, pp 56–63

Update on the Prevention of Type 2 Diabetes

Article

DOI: 10.1007/s11892-010-0163-x

Cite this article as:
Karam, J.G. & McFarlane, S.I. Curr Diab Rep (2011) 11: 56. doi:10.1007/s11892-010-0163-x

Abstract

Diabetes has emerged as the modern day epidemic that is currently affecting over 220 million people worldwide and claiming at least 1.1 million lives in 2005 alone. The rise in diabetes is largely attributed to the epidemic of obesity together with sedentary lifestyle as well as unhealthy dietary habits. Despite evidence that glycemic control as well as control of other cardiovascular disease (CVD) risk factors such as hypertension and dyslipidemia decreases morbidity and mortality in the diabetic population, control of glycemia and other CVD risk factors remains largely suboptimal making the concept of prevention of diabetes very appealing to control CVD risk, especially that such a risk is already increased in people in the prediabetic stage. Several large controlled trials have been completed testing various options for diabetes prevention. In this paper we present an update on prevention of type 2 diabetes highlighting the major recent trials completed to date in this very important area of investigation.

Keywords

Diabetes Prevention Prediabetes Impaired fasting glucose Impaired glucose tolerance 

Clinical Trial Acronyms

ACT NOW

Actos Now for Prevention of Diabetes

ALLHAT

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

BIP

Bezafibrate Infarction Prevention

CANOE

Canadian Normoglycemia Outcomes Evaluation

CAPP

Captopril Prevention Project

DPP

Diabetes Prevention Program

DREAM

Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medications

HOPE

Heart Outcomes Prevention Evaluation

LIFE

Losartan Intervention for Endpoint Reduction in Hypertension study

NAVIGATOR

Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research

SOS

Swedish Obese Subjects

STOP-NIDDM

Study to Prevent Non-Insulin Dependent Diabetes Mellitus

TRIPOD

Troglitazone in Prevention of Diabetes

WOSCOPS

West of Scotland Coronary Prevention Study

XENDOS

Xenical in the Prevention of Diabetes in Obese Subjects.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Maimonides Medical CenterBrooklynUSA

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