Current Diabetes Reports

, Volume 10, Issue 2, pp 93–100

Insulin, Insulin Resistance, Obesity, and Cancer

Article

DOI: 10.1007/s11892-010-0101-y

Cite this article as:
Gallagher, E.J. & LeRoith, D. Curr Diab Rep (2010) 10: 93. doi:10.1007/s11892-010-0101-y
  • 418 Downloads

Abstract

Epidemiologic studies have proposed a link between obesity, type 2 diabetes, and cancer. The pathophysiologic mechanisms involved in the development of type 2 diabetes, namely hyperinsulinemia and insulin resistance, have also been implicated in cancer development. Patients with type 2 diabetes are reported to have a worse response to cancer chemotherapy, have more complications, and have a poorer prognosis than patients with cancer without diabetes. Studies also have reported that insulin, insulin secretagogues, and metformin may have effects on tumor growth. Given the escalating worldwide prevalence of obesity and type 2 diabetes, their relationship to cancer has generated great interest and research across many fields of medicine.

Keywords

Insulin Insulin-like growth factor-1 Obesity Cancer Diabetes 

Clinical Trial Acronyms

CPS II

Cancer Prevention Study II

EPIC

European Prospective Investigation Into Cancer and Nutrition

NECSS

National Enhanced Cancer Surveillance System

NHANES III

Third National Health and Nutrition Examination Survey

WHI

Women’s Health Initiative

ZODIAC-16

Zwolle Outpatient Diabetes Project Integrating Available Care 16.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Endocrinology, Department of MedicineMount Sinai School of MedicineNew YorkUSA

Personalised recommendations