Current Diabetes Reports

, Volume 10, Issue 2, pp 90–92 | Cite as

The Presence and Role of Brown Fat in Adult Humans

Article

Abstract

Over the past decade, studies in nuclear medicine using positron-emisson tomography in conjunction with computed tomography (PET/CT) clearly revealed the presence of brown adipose tissue (BAT) in adult humans. Last year, highly publicized papers suggested a potential role for BAT to regulate not only human body temperature but possibly energy balance. Whether BAT can be up regulated in adult humans remain to be shown? Furthermore, the potential role of BAT in the regulation of energy balance needs to be investigated in response to overfeeding.

Keywords

Brown fat UCP1 BAT 18F-FDG 

References

  1. 1.
    Nedergaard J, Bengtsson T, Cannon B: Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007, 293:E444–E452.CrossRefPubMedGoogle Scholar
  2. 2.
    Tatsumi M, Engles JM, Ishimori T, et al.: Intense (18)F-FDG uptake in brown fat can be reduced pharmacologically. J Nucl Med 2004, 45:1189–1193.PubMedGoogle Scholar
  3. 3.
    Baba S, Engles JM, Huso DL, et al.: Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions. J Nucl Med 2007, 48:1715–1723.CrossRefPubMedGoogle Scholar
  4. 4.
    Hadi M, Chen CC, Whatley M, et al.: Brown fat imaging with (18)F-6-fluorodopamine PET/CT, (18)F-FDG PET/CT, and (123)I-MIBG SPECT: a study of patients being evaluated for pheochromocytoma. J Nucl Med 2007, 48:1077–1083.CrossRefPubMedGoogle Scholar
  5. 5.
    Baba S, Tatsumi M, Ishimori T, et al.: Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue. J Nucl Med 2007, 48:981–986.CrossRefPubMedGoogle Scholar
  6. 6.
    Cohade C, Mourtzikos KA, Wahl RL: “USA-Fat”: prevalence is related to ambient outdoor temperature-evaluation with 18F-FDG PET/CT. J Nucl Med 2003, 44:1267–1270.PubMedGoogle Scholar
  7. 7.
    Cohade C, Osman M, Pannu HK, Wahl RL: Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT. J Nucl Med 2003, 44:170–176.PubMedGoogle Scholar
  8. 8.
    Virtanen KA, Lidell ME, Orava J, et al.: Functional brown adipose tissue in healthy adults. N Engl J Med 2009, 360:1518–1525.CrossRefPubMedGoogle Scholar
  9. 9.
    van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al.: Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009, 360:1500–1508.Google Scholar
  10. 10.
    Cypess AM, Lehman S, Williams G, et al.: Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009, 360:1509–1517.CrossRefPubMedGoogle Scholar
  11. 11.
    Saito M, Okamatsu-Ogura Y, Matsushita M, et al.: High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009, 58:1526–1531.CrossRefPubMedGoogle Scholar
  12. 12.
    Heaton GM, Wagenvoord RJ, Kemp A Jr, Nicholls DG: Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur J Biochem 1978, 82:515–521.CrossRefPubMedGoogle Scholar
  13. 13.
    Ricquier D, Kader JC: Mitochondrial protein alteration in active brown fat: a sodium dodecyl sulfate-polyacrylamide gel electrophoretic study. Biochem Biophys Res Commun 1976, 73:577–583.CrossRefPubMedGoogle Scholar
  14. 14.
    Ghorbani M, Himms-Hagen J: Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 1997, 21:465–475.CrossRefPubMedGoogle Scholar
  15. 15.
    Cummings DE, Brandon EP, Planas JV, et al.: Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 1996, 382:622–626.CrossRefPubMedGoogle Scholar
  16. 16.
    Kopecky J, Clarke G, Enerbäck S, et al.: Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995, 96:2914–2923.CrossRefPubMedGoogle Scholar
  17. 17.
    Seale P, Bjork B, Yang W, et al.: PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961–967.CrossRefPubMedGoogle Scholar
  18. 18.
    Xue B, Rim JS, Hogan JC, et al.: Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 2007, 48:41–51.CrossRefPubMedGoogle Scholar
  19. 19.
    Tseng YH, Kokkotou E, Schulz TJ, et al.: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008, 454:1000–1004.CrossRefPubMedGoogle Scholar
  20. 20.
    Ravussin E, Kozak LP: Have we entered the brown adipose tissue renaissance? Obes Rev 2009, 10:265–268.CrossRefPubMedGoogle Scholar
  21. 21.
    Wijers SL, Saris WH, van Marken Lichtenbelt WD: Individual thermogenic responses to mild cold and overfeeding are closely related. J Clin Endocrinol Metab 2007, 92:4299–4305.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Pennington Biomedical Research CenterBaton RougeUSA

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