Current Diabetes Reports

, Volume 10, Issue 1, pp 16–23

Multifactorial Intervention to Reduce Cardiovascular Events in Type 2 Diabetes

  • Swapnil N. Rajpathak
  • Vikas Aggarwal
  • Frank B. Hu


Type 2 diabetes is associated with a significantly increased risk of cardiovascular disease (CVD) morbidity and mortality. Although several clinical trials have evaluated the effects of interventions to reduce CVD risk in people with diabetes, such studies are primarily conducted to target individual risk factors such as hypertension, hyperglycemia, and dyslipidemia rather than using a multifactorial interventional approach. Existing clinical trial data suggest that intensive multifactorial interventions that target several important risk factors simultaneously result in a significantly greater risk reduction in CVD risk compared with single risk factor interventions. However, few studies have evaluated the efficacy and effectiveness of such interventions on CVD hard end points. A multidisciplinary team management of diabetes should focus on weight control, diet, physical activity, diabetes education, and adherence to pharmacotherapy. An individually tailored aggressive management program to reduce multiple CVD risk factors simultaneously has great potential to prevent CVD morbidity and mortality among patients with type 2 diabetes.


Diabetes Cardiovascular disease Multifactorial intervention Lifestyle intervention Nutrition Lipids Obesity Hypertension Hypoglycemia 


Papers of particular interest, published recently, have been highlighted as follows: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Swapnil N. Rajpathak
    • 1
  • Vikas Aggarwal
    • 1
  • Frank B. Hu
    • 2
  1. 1.Department of Epidemiology and Population Health, Albert Einstein College of MedicineNew YorkUSA
  2. 2.Departments of Nutrition and EpidemiologyHarvard School of Public HealthBostonUSA

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