Current Diabetes Reports

, Volume 9, Issue 1, pp 51–59 | Cite as

Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap

  • Roger S. McIntyre
  • Natalie L. Rasgon
  • David E. Kemp
  • Ha T. Nguyen
  • Candy W. Y. Law
  • Valerie H. Taylor
  • Hanna O. Woldeyohannes
  • Mohammad T. Alsuwaidan
  • Joanna K. Soczynska
  • Byungsu Kim
  • Maria T. Lourenco
  • Linda S. Kahn
  • Benjamin I. Goldstein
Article

Abstract

The metabolic syndrome and its components are associated with depressive symptomatology. This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder.

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References and Recommended Reading

  1. 1.
    Gans RO: The metabolic syndrome, depression, and cardiovascular disease: interrelated conditions that share pathophysiologic mechanisms. Med Clin North Am 2006, 90:573–591.PubMedCrossRefGoogle Scholar
  2. 2.
    Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002, 287:356–359.PubMedCrossRefGoogle Scholar
  3. 3.
    Hu G, Qiao Q, Tuomilehto J, et al.: Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004, 164:1066–1076.PubMedCrossRefGoogle Scholar
  4. 4.
    Laaksonen DE, Lakka HM, Niskanen LK, et al.: Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 2002, 156:1070–1077.PubMedCrossRefGoogle Scholar
  5. 5.
    Grundy SM, Cleeman JI, Daniels SR, et al.: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112:2735–2752.PubMedCrossRefGoogle Scholar
  6. 6.
    Rasgon NL, Altshuler LL, Fairbanks L, et al.: Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disord 2005, 7:246–259.PubMedCrossRefGoogle Scholar
  7. 7.
    Lindley SE, Schroder CM, O’Hara R, Fazio S: Insulin resistance in schizophrenia, major depression, and bipolar disorder. In Insulin Resistance Syndrome and Neuropsychiatric Disease. Edited by Rasgon NL. New York: Informa Healthcare; 2008:49–86.Google Scholar
  8. 8.
    Taylor V, Macqueen G: Associations between bipolar disorder and metabolic syndrome: a review. J Clin Psychiatry 2006, 67:1034–1041.PubMedGoogle Scholar
  9. 9.
    McEvoy JP, Meyer JM, Goff DC, et al.: Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr Res 2005, 80:19–32.PubMedCrossRefGoogle Scholar
  10. 10.
    Fagiolini A, Frank E, Scott JA, et al.: Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians. Bipolar Disord 2005, 7:424–430.PubMedCrossRefGoogle Scholar
  11. 11.
    Fagiolini A, Frank E, Turkin S, et al.: Metabolic syndrome in patients with bipolar disorder. J Clin Psychiatry 2008, 69:678–679.PubMedCrossRefGoogle Scholar
  12. 12.
    Van WR, De HM, Van ED, et al.: Prevalence of diabetes and the metabolic syndrome in a sample of patients with bipolar disorder. Bipolar Disord 2008, 10:342–348.CrossRefGoogle Scholar
  13. 13.
    Gavard JA, Lustman PJ, Clouse RE: Prevalence of depression in adults with diabetes. An epidemiological evaluation. Diabetes Care 1993, 16:1167–1178.PubMedCrossRefGoogle Scholar
  14. 14.
    Teixeira PJ, Rocha FL: The prevalence of metabolic syndrome among psychiatric inpatients in Brazil. Rev Bras Psiquiatr 2007, 29:330–336.PubMedCrossRefGoogle Scholar
  15. 15.
    Koponen H, Jokelainen J, Keinanen-Kiukaanniemi S, et al.: Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study. J Clin Psychiatry 2008, 23:e1–e5.Google Scholar
  16. 16.
    McIntyre RS, Soczynska JK, Konarski JZ, et al.: Should depressive syndromes be reclassified as “metabolic syndrome type II”? Ann Clin Psychiatry 2007, 19:257–264.PubMedCrossRefGoogle Scholar
  17. 17.
    McIntyre RS, Soczynska JK, Konarski JZ, et al.: The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms. Expert Opin Drug Saf 2006, 5:157–168.PubMedCrossRefGoogle Scholar
  18. 18.
    McIntyre RS, Soczynska JK, Konarski JZ, et al.: The effect of antidepressants on lipid homeostasis: a cardiac safety concern? Expert Opin Drug Saf 2006, 5:523–537.PubMedCrossRefGoogle Scholar
  19. 19.
    Kinder LS, Carnethon MR, Palaniappan LP, et al.: Depression and the metabolic syndrome in young adults: findings from the Third National Health and Nutrition Examination Survey. Psychosom Med 2004, 66:316–322.PubMedCrossRefGoogle Scholar
  20. 20.
    Gil K, Radzillowicz P, Zdrojewski T, et al.: Relationship between the prevalence of depressive symptoms and metabolic syndrome. Results of the SOPKARD Project. Kardiol Pol 2006, 64:464–469.PubMedCrossRefGoogle Scholar
  21. 21.
    Raikkonen K, Matthews KA, Kuller LH: Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women: a comparison of World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation definitions. Diabetes Care 2007, 30:872–877.PubMedCrossRefGoogle Scholar
  22. 22.
    Roos C, Lidfeldt J, Agardh CD, et al.: Insulin resistance and self-rated symptoms of depression in Swedish women with risk factors for diabetes: the Women’s Health in the Lund Area study. Metabolism 2007, 56:825–829.PubMedCrossRefGoogle Scholar
  23. 23.
    Raikkonen K, Matthews KA, Kuller LH: The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence? Metabolism 2002, 51:1573–1577.PubMedCrossRefGoogle Scholar
  24. 24.
    McCaffery JM, Niaura R, Todaro JF, et al.: Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung, and Blood Institute twin study. Psychosom Med 2003, 65:490–497.PubMedCrossRefGoogle Scholar
  25. 25.
    Heiskanen TH, Niskanen LK, Hintikka JJ, et al.: Metabolic syndrome and depression: a cross-sectional analysis. J Clin Psychiatry 2006, 67:1422–1427.PubMedCrossRefGoogle Scholar
  26. 26.
    Skilton MR, Moulin P, Terra JL, et al.: Associations between anxiety, depression, and the metabolic syndrome. Biol Psychiatry 2007, 62:1251–1257.PubMedCrossRefGoogle Scholar
  27. 27.
    Vaccarino V, McClure C, Johnson BD, et al.: Depression, the metabolic syndrome and cardiovascular risk. Psychosom Med 2008, 70:40–48.PubMedCrossRefGoogle Scholar
  28. 28.
    Frasure-Smith N, Lesperance F, Talajic M: Depression following myocardial infarction. Impact on 6-month survival. JAMA 1993, 270:1819–1825.PubMedCrossRefGoogle Scholar
  29. 29.
    Osby U, Brandt L, Correia N, et al.: Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry 2001, 58:844–850.PubMedCrossRefGoogle Scholar
  30. 30.
    Kashyap S, Belfort R, Gastaldelli A, et al.: A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 2003, 52:2461–2474.PubMedCrossRefGoogle Scholar
  31. 31.
    Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37:1595–1607.PubMedCrossRefGoogle Scholar
  32. 32.
    Sarafidis PA, Bakris GL: Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance? J Hum Hypertens 2007, 21:12–19.PubMedCrossRefGoogle Scholar
  33. 33.
    McIntyre RS, Konarski JZ, Wilkins K, et al.: Obesity in bipolar disorder and major depressive disorder: results from a national community health survey on mental health and well-being. Can J Psychiatry 2006, 51:274–280.PubMedCrossRefGoogle Scholar
  34. 34.
    Lapidus L, Bengtsson C, Larsson B, et al.: Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J (Clin Res Ed) 1984, 289:1257–1261.Google Scholar
  35. 35.
    Kalkhoff RK, Hartz AH, Rupley D, et al.: Relationship of body fat distribution to blood pressure, carbohydrate tolerance, and plasma lipids in healthy obese women. J Lab Clin Med 1983, 102:621–627.PubMedGoogle Scholar
  36. 36.
    Peiris AN, Sothmann MS, Hennes MI, et al.: Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis: predictive values of selected indices in premenopausal women. Am J Clin Nutr 1989, 49:758–764.PubMedGoogle Scholar
  37. 37.
    Lee ES, Kim YH, Beck SH, et al.: Depressive mood and abdominal fat distribution in overweight premenopausal women. Obes Res 2005, 13:320–325.PubMedCrossRefGoogle Scholar
  38. 38.
    Moreira RO, Marca KF, Appolinario JC, et al.: Increased waist circumference is associated with an increased prevalence of mood disorders and depressive symptoms in obese women. Eat Weight Disord 2007, 12:35–40.PubMedGoogle Scholar
  39. 39.
    Southwick SM, Vythilingam M, Charney DS: The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol 2005, 1:255–291.PubMedCrossRefGoogle Scholar
  40. 40.
    Banki CM, Karmacsi L, Bissette G, et al.: CSF corticotropin-releasing hormone and somatostatin in major depression: response to antidepressant treatment and relapse. Eur Neuropsychopharmacol 1992, 2:107–113.PubMedCrossRefGoogle Scholar
  41. 41.
    Kapczinski F, Vieta E, Andreazza AC, et al.: Allostatic load in bipolar disorder: Implications for pathophysiology and treatment. Neurosci Biobehav Rev 2008, 32:675–692.PubMedCrossRefGoogle Scholar
  42. 42.
    Craft S, Watson GS: Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 2004, 3:169–178.PubMedCrossRefGoogle Scholar
  43. 43.
    Girgis RR, Javitch JA, Lieberman JA:Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway. Mol Psychiatry 2008, 13:918–929.PubMedCrossRefGoogle Scholar
  44. 44.
    Gould TD, Manji HK: Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology 2005, 30:1223–1237.PubMedGoogle Scholar
  45. 45.
    Raison CL, Capuron L, Miller AH: Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006, 27:24–31.PubMedCrossRefGoogle Scholar
  46. 46.
    Kiecolt-Glaser JK, Glaser R: Depression and immune function: central pathways to morbidity and mortality. J Psychosom Res 2002, 53:873–876.PubMedCrossRefGoogle Scholar
  47. 47.
    Selley ML: Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression. J Affect Disord 2004, 80:249–256.PubMedCrossRefGoogle Scholar
  48. 48.
    Sarandol A, Sarandol E, Eker SS, et al.: Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum Psychopharmacol 2007, 22:67–73.PubMedCrossRefGoogle Scholar
  49. 49.
    Sarandol A, Sarandol E, Eker SS, et al.: Oxidation of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30:1103–1108.PubMedCrossRefGoogle Scholar
  50. 50.
    Maiese K, Morhan SD, Chong ZZ: Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 2007, 4:63–71.PubMedCrossRefGoogle Scholar
  51. 51.
    Forlenza MJ, Miller GE: Increased serum levels of 8-hydroxy-2′-deoxyguanosine in clinical depression. Psychosom Med 2006, 68:1–7.PubMedCrossRefGoogle Scholar
  52. 52.
    Carney RM, Freedland KE, Veith RC: Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med 2005, 67(Suppl 1):S29–S33.PubMedCrossRefGoogle Scholar
  53. 53.
    Carnethon MR, Golden SH, Folsom AR, et al.: Prospective investigation of autonomic nervous system function and the development of type 2 diabetes: the Atherosclerosis Risk In Communities study, 1987–1998. Circulation 2003, 107:2190–2195.PubMedCrossRefGoogle Scholar
  54. 54.
    Golden RN, Markey SP, Risby ED, et al.: Antidepressants reduce whole-body norepinephrine turnover while enhancing 6-hydroxymelatonin output. Arch Gen Psychiatry 1988, 45:150–154.PubMedGoogle Scholar
  55. 55.
    Benthem L, Keizer K, Wiegman CH et al.: Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation. Am J Physiol Endocrinol Metab 2000, 279:E1286–E1293.PubMedGoogle Scholar
  56. 56.
    McIntyre RS, McElroy SL, Konarski JZ, et al.: Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions. J Clin Psychiatry 2007, 68:1352–1357.PubMedCrossRefGoogle Scholar
  57. 57.
    Rasgon NL, Kenna HA: Insulin resistance in depressive disorders and Alzheimer’s disease: revisiting the missing link hypothesis. Neurobiol Aging 2005, 26(Suppl 1):103–107.PubMedCrossRefGoogle Scholar
  58. 58.
    Dunn AL, Trivedi MH, Kampert JB, et al.: Exercise treatment for depression: efficacy and dose response. Am J Prev Med 2005, 28:1–8.PubMedCrossRefGoogle Scholar

Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  • Roger S. McIntyre
    • 1
  • Natalie L. Rasgon
  • David E. Kemp
  • Ha T. Nguyen
  • Candy W. Y. Law
  • Valerie H. Taylor
  • Hanna O. Woldeyohannes
  • Mohammad T. Alsuwaidan
  • Joanna K. Soczynska
  • Byungsu Kim
  • Maria T. Lourenco
  • Linda S. Kahn
  • Benjamin I. Goldstein
  1. 1.Mood Disorders Psychopharmacology UnitUniversity Health NetworkTorontoCanada

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