Current Diabetes Reports

, Volume 8, Issue 4, pp 263–269

Novel potential mechanisms for diabetic macular edema: Leveraging new investigational approaches


DOI: 10.1007/s11892-008-0047-5

Cite this article as:
Gardner, T.W. & Antonetti, D.A. Curr Diab Rep (2008) 8: 263. doi:10.1007/s11892-008-0047-5


This article evaluates the current knowledge of the molecular mechanisms by which diabetes ocular and systemic inflammation induce breakdown of the blood-retinal barrier resulting in macular edema. We also summarize the relationship between molecular targets and the use of therapeutic inhibitors in preclinical studies and clinical trials. Further studies are needed to understand the regulation of normal blood-retinal barrier physiology and the relationship between events in animal models of diabetic retinopathy and humans with diabetes.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Departments of Ophthalmology and Cellular and Molecular PhysiologyPenn State College of MedicineHersheyUSA

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