Current Diabetes Reports

, Volume 8, Issue 3, pp 185–191

Ectopic fat and insulin resistance

Article

DOI: 10.1007/s11892-008-0032-z

Cite this article as:
Lettner, A. & Roden, M. Curr Diab Rep (2008) 8: 185. doi:10.1007/s11892-008-0032-z

Abstract

Ectopic fat is defined by the deposition of triglycerides within cells of non-adipose tissue that normally contain only small amounts of fat. Over the past decade, magnetic resonance spectroscopy has been used extensively for noninvasive quantification of intramyocellular, intrahepatocellular, and more recently myocardial and pancreatic lipids. In liver and muscle, triglyceride content usually correlates with whole-body and tissue-specific insulin sensitivity. However, fat mass and oxidative capacity influence this relationship, indicating that ectopic lipid content is not the only factor that explains insulin resistance. Ectopic lipids may rather serve as biomarkers of the balance between metabolic supply and demand in different states of insulin sensitivity. Consequently, ectopic lipid concentrations, particularly in the liver, decrease with lifestyle-or drug-induced improvement of insulin sensitivity.

Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.Medical DepartmentHanusch Hospital, Karl-Landsteiner Institute of Endocrinology and MetabolismViennaAustria

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