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Current Diabetes Reports

, Volume 8, Issue 1, pp 51–59 | Cite as

Why is HDL functionally deficient in type 2 diabetes?

  • Anatol KontushEmail author
  • M. John Chapman
Article

Abstract

High-lipoprotein (HDL) particles exert a spectrum of atheroprotective activities that can be deficient in type 2 diabetes. Key mechanisms leading to the formation of functionally deficient HDL involve 1) HDL enrichment in triglycerides and depletion in cholesteryl esters with conformational alterations of apolipoprotein A-I; 2) glycation of apolipoproteins and/or HDL-associated enzymes; and 3) oxidative modification of HDL lipids, apolipoproteins, and/or enzymes. Available data identify hypertriglyceridemia, with concomitant compositional modification of the HDL lipid core and conformational change of apolipoprotein A-I, as a driving force in functional alteration of HDL particles in type 2 diabetes. Therapeutic options for correcting HDL functional deficiency should target hypertriglyceridemia by normalizing circulating levels of triglyceride-rich lipoproteins.

Keywords

Cholesteryl Ester Transfer Protein Arterioscler Thromb Vasc Biol PON1 Activity Cholesteryl Ester Transfer Protein Inhibitor Human Acute Monocytic Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  1. 1.INSERM Unité 551, Pavillon Benjamin DelessertHôpital de la PitiéParis Cedex 13France

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