Current Diabetes Reports

, Volume 7, Issue 3, pp 235–241 | Cite as

Glycotoxins in the diet promote diabetes and diabetic complications

Article

Abstract

Oxidant stress underlies diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation end products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients and complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.

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Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Division of Experimental Diabetes and Aging, Department of GeriatricsMount Sinai School of MedicineNew YorkUSA

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