Current Diabetes Reports

, Volume 5, Issue 5, pp 346–352 | Cite as

Utilizing the GLP-1 signaling system to treat diabetes: Sorting through the pharmacologic approaches

  • David A. D’Alessio
  • Torsten P. Vahl


cagon-like peptide-1 (GLP-1) is an intestinal hormone that promotes glucose homeostasis through the regulation of insulin and glucagon secretion, gastric emptying, and food intake. This spectrum of effects makes GLP-1 an attractive candidate for drug development. However, because GLP-1 is a small peptide with rapid metabolism in the circulation, its usefulness to treat patients is limited. However, GLP-1 mimetics that are resistant to degradation have been developed and are effective in lowering blood glucose in diabetic patients. A second strategy for harnessing GLP-1 therapeutically is to inhibit the metabolism of endogenous GLP-1; several orally available compounds are in clinical trials. These two new classes of drugs both enhance GLP-1 signaling but differ in several key characteristics that may lead to distinct roles in the treatment of diabetic patients.


Metformin Liraglutide Exenatide Gastric Inhibitory Polypeptide Dipeptidyl Peptidase 
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Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • David A. D’Alessio
    • 1
  • Torsten P. Vahl
    • 1
  1. 1.Division of Endocrinology/MetabolismUniversity of CincinnatiCincinnatiUSA

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