Current Diabetes Reports

, Volume 5, Issue 2, pp 149–156 | Cite as

The role of HNF4A variants in the risk of type 2 diabetes

  • Karen L. Mohlke
  • Michael Boehnke


Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping recently identified a likely susceptibility gene, hepatocyte nuclear factor 4-α (HNF4A). Rare loss-of-function mutations in HNF4A cause maturityonset diabetes of the young and now common noncoding variants have been found to be associated with T2DM.


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Copyright information

© Current Science Inc. 2005

Authors and Affiliations

  • Karen L. Mohlke
    • 1
  • Michael Boehnke
  1. 1.Department of GeneticsUniversity of North CarolinaChapel HillUSA

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