Current Diabetes Reports

, Volume 5, Issue 2, pp 91–97

Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications

  • Yizhen Xu
  • Zhiheng He
  • George L. King

DOI: 10.1007/s11892-005-0034-z

Cite this article as:
Xu, Y., He, Z. & King, G.L. Curr Diab Rep (2005) 5: 91. doi:10.1007/s11892-005-0034-z


Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end products; increased oxidative stress; activation of protein kinase C pathway; increased activity of hexosamine pathway; and vascular inflammation and the impairment of insulin action in the vascular tissues.

Copyright information

© Current Science Inc. 2005

Authors and Affiliations

  • Yizhen Xu
  • Zhiheng He
  • George L. King
    • 1
  1. 1.Joslin Diabetes CenterHarvard Medical SchoolBostonUSA

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