The role of electron beam computed tomography for measuring coronary artery atherosclerosis
- 19 Downloads
It is generally agreed that the coronary artery calcium score provides significant information for the prediction of future cardiac events. However, additional information is needed to determine whether or not this information is significantly greater than that available from the analysis of established risk factors. Until this is resolved, it is unlikely that electron beam computed tomography can be justified for routine evaluation of patients. However, measurement of coronary artery calcium may be valuable in selected clinical situations, and has potential as a research tool for studying the pathogenesis or treatment of stable coronary artery disease.
KeywordsCoronary Artery Calcium Coronary Artery Calcium Score Arterioscler Thromb Vasc Biol Cardiac Risk Factor Electron Beam Compute Tomography
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 1.Wilson PWF, Kannel WB: Epidemiology of hyperglycemia and atherosclerosis. In Hyperglycemia, Diabetes, and Vascular Disease. Edited by Ruderman N, et al. New York: Oxford University Press; 1992:21–29.Google Scholar
- 13.Schurgin S, Rich S, Mazzone T: Increased prevalence of significant coronary artery calcification in patients with diabetes. Diabetes Care 2001, 24:335–338. Illustrates that the distribution of CACS is shifted to higher levels in patients with diabetes even after matching for coronary artery risk factors.PubMedCrossRefGoogle Scholar
- 17.Olson JC, Edmundowicz D, Becker DJ, et al.: Coronary calcium in adults with type 1 diabetes: a stronger correlate of clinical coronary artery disease in men than in women. Diabetes 2000, 49:1571–1578. Establishes a significant relationship between elevated coronary artery calcium and clinical evidence of CAD in patients with type 1 diabetes.PubMedCrossRefGoogle Scholar
- 21.Falk E, Shah P, Fuster V: Coronary plaque disruption. Circulation 1995, 92:656–671.Google Scholar
- 28.Kondos GT, Hoff JA, Seyrukov A, et al.: Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation 2003, 107:2571–2576. Examined a large number of patients and demonstrated that an elevated CACS provided significant incremental information, over that provided by conventional CAD risk factor assessment, for predicting future cardiac events.PubMedCrossRefGoogle Scholar
- 39.Rosenfeld ME, Kauser K, Martin-McNulty R, et al.: Estrogen inhibits the initiation of fatty streaks throughout the vasculature but does not inhibit intra-plaque hemorrhage and the progression of established lesions in apolipoprotein E deficient mice. Atherosclerosis 2002, 164:251–259.PubMedCrossRefGoogle Scholar
- 41.Akhrass F, Evans AT, Wang Y, et al.: Hormone replacement therapy is associated with less coronary atherosclerosis in postmenopausal women. J Clin Endocrinol Metab 2003, in press.Google Scholar