Current Diabetes Reports

, Volume 3, Issue 2, pp 159–167 | Cite as

Growing evidence for diabetes susceptibility genes from genome scan data

  • Mark I. McCarthy


Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain- 10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed.


Susceptibility Locus Genome Scan Diabetes Susceptibility Diabetes Susceptibility Gene Multifactorial Trait 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc. 2003

Authors and Affiliations

  • Mark I. McCarthy
    • 1
  1. 1.Endocrinology and Metabolism, and Wellcome Trust Centre for Human GeneticsOxford Centre for DiabetesOxfordUK

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