Current Diabetes Reports

, Volume 3, Issue 2, pp 151–158 | Cite as

The genetics of adiponectin

  • Francis Vasseur
  • Frédéric Leprêtre
  • Corinne Lacquemant
  • Philippe Froguel


Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM 1 gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APM 1 gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APM 1 gene and questions that genetic data raise.


Insulin Resistance Genetic Modulation Adiponectin Level Insulin Resistance Syndrome Serum Adiponectin Level 
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Copyright information

© Current Science Inc. 2003

Authors and Affiliations

  • Francis Vasseur
    • 1
  • Frédéric Leprêtre
    • 1
  • Corinne Lacquemant
  • Philippe Froguel
    • 1
  1. 1.CNRS UMR 8090Institut de Biologie de Lille, Institut Pasteur de LilleLille cedexFrance

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